Preventive Effects of Polyprenols from the Needles of Aabies sibirica under the Influence of Adverse Factors
https://doi.org/10.33647/2074-5982-20-3-89-93
Abstract
Currently, biologically active substances of natural origin are widely used as preventative agents. The search and development of new drugs for the prevention and correction of nonspecific disorders of the body’s resistance to adverse effects in environment continues. A preclinic assessment of the effectiveness of polyprenols from Siberian fir Abies sibirica was carried out when used prophylactically for two weeks. It has been shown that the effect of polyprenols is manifested by antioxidant, anabolic activity and stimulation of hematopoiesis in an experimental model of combined poisoning with carbendazim and X-ray irradiation.
Supporting agencies: this work was performed in the framework of State task of the Federal Medical Biological Agency of Russia No. 388-00113-21-00 (code 64.003.21.800).
About the Authors
M. V. Melnikova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Margarita V. Melnikova
192019, Saint Petersburg, Bekhtereva Str., 1
E. B. Shustov
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Evgeniy B. Shustov, Dr. Sci. (Med.), Prof.
192019, Saint Petersburg, Bekhtereva Str., 1
E. A. Zolotoverkhaya
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Ekaterina A. Zolotoverkhaya
192019, Saint Petersburg, Bekhtereva Str., 1
L. G. Kubarskaya
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Larisa G. Kubarskaya
192019, Saint Petersburg, Bekhtereva Str., 1
A. A. Bondarenko
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Anastasiya A. Bondarenko
192019, Saint Petersburg, Bekhtereva Str., 1
A. V. Belskaya
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Alisa V. Belskaya
192019, Saint Petersburg, Bekhtereva Str., 1
A. A. Vataeva
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Alena A. Vataeva
192019, Saint Petersburg, Bekhtereva Str., 1
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Review
For citations:
Melnikova M.V., Shustov E.B., Zolotoverkhaya E.A., Kubarskaya L.G., Bondarenko A.A., Belskaya A.V., Vataeva A.A. Preventive Effects of Polyprenols from the Needles of Aabies sibirica under the Influence of Adverse Factors. Journal Biomed. 2024;20(3):89-93. (In Russ.) https://doi.org/10.33647/2074-5982-20-3-89-93
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