Experimental Models for Screening First Aid Medications for Convulsive Syndrome of Obscure Etiology

Abstract

Three experimental models suitable for screening first aid medications for seizures of obscure etiology are developed. Hypobaric exposure in a pressure chamber at an “altitude” of 12 km, intraperitoneal administration of a 50% N-methylpyrrolidone solution of camphor in a volume of 2 ml/kg, or an aqueous solution of ammonium acetate in a dose of 770 mg/kg were used to induce convulsions in rats. Seizure latency time and lethality are proposed as necessary and sufficient criteria for assessing the effectiveness of tested pharmaceuticals. The developed models make it possible to evaluate the efficacy of potential anticonvulsants in the mode of emergency prevention or seizure relief. Due to the versatility of the neurotoxicity pathways of the convulsive agents, these experimental models are suitable for identifying anticonvulsants that are effective in convulsive syndrome of obscure etiology.