Comparative Analysis of Effects of Chloral Hydrate and Tribromoethanol on Electroneuromyographic Parameters in Mice
https://doi.org/10.33647/2713-0428-20-3E-89-93
Abstract
Selection of an optimal general anesthesia regimen is an essential prerequisite for the conduction of electrophysiological tests in laboratory animals. In this work, we compared the effects of two general anesthetic drugs commonly used in preclinical studies, i.e., chloral hydrate (CH) and tribromoethanol (TBE), on the parameters of neuromuscular function in outbred mice. CH and TBE were found to distinctly affect peripheral nerve conductivity and skeletal muscle contractility recovery following electrical stimulation-induced fatigue.
About the Authors
V. A. Prikhodko
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia;
N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Veronika A. Prikhodko, Cand. Sci. (Biol.)
197376, Saint Petersburg, Professora Popova Str., 14, lit. A;
197376, St. Petersburg, Akademika Pavlova Str., 12, lit. A
T. M. Matuzok
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia;
N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Tatyana M. Matuzok
197376, Saint Petersburg, Professora Popova Str., 14, lit. A;
197376, St. Petersburg, Akademika Pavlova Str., 12, lit. A
N. O. Selizarova
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Natalya O. Selizarova, Cand. Sci. (Med.), Assoc. Prof.
197376, Saint Petersburg, Professora Popova Str., 14, lit. A
S. V. Okovitiy
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia;
N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Sergey V. Okovitiy, Dr. Sci. (Med.), Prof.
197376, Saint Petersburg, Professora Popova Str., 14, lit. A;
197376, St. Petersburg, Akademika Pavlova Str., 12, lit. A
References
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Review
For citations:
Prikhodko V.A., Matuzok T.M., Selizarova N.O., Okovitiy S.V. Comparative Analysis of Effects of Chloral Hydrate and Tribromoethanol on Electroneuromyographic Parameters in Mice. Journal Biomed. 2024;20(3E):89-93. (In Russ.) https://doi.org/10.33647/2713-0428-20-3E-89-93
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