Modification of Rat Cardiovascular System Parameters in an Ischemia-Reperfusion Model Using Extremely High Frequency Electromagnetic Radiation

The article presents the results of studying the parameters of the cardiovascular system (CVS) in rats under conditions of ischemic-reperfusion simulation and exposure to electromagnetic radiation of extremely high frequency (EHF EMR). The aim was to identify changes in CVS parameters in rats during the postischemic period following preventive EHF exposure.
The experiment was carried out on 30 mature male Wistar rats weighing between 200 and 220 g, which were housed in a vivarium under a natural light-dark schedule. Using a modified block randomization method, the animals were split into three groups with 10 rats in each: group 1 included sham-operated (SO) animals, which underwent surgery according to the operation plan but without occlusion of the left carotid artery; group 2 included truly operated animals who underwent surgery and had the left common carotid occluded (CCO) in accordance with the plan; and group 3 (EHF) included animals that underwent preventive 10-fold action of low-intensity EHF EMR followed by ischemia-reperfusion modelling (on the 10th day, after 60 min after the 10th session of EHF exposure) and OCA occlusion.
It is shown that the modelled ischemia-reperfusion of the brain is associated with a strain of the physiological reserves of the CVS and the body as a whole. Thus, an increase in systemic blood pressure, heart rate, sympathetic effects on the CVS, energy costs, and oxygen consumption by cardiomyocytes is observed. Recovery of CVS indicators to the level of SO is observed on the 3rd day after ischemia.
It was found that preventive 10-fold exposure to EHF mitigates the effect of ischemia, which is reflected in a decrease in all CVS indicators (except for PP). This increases adaptive capabilities of the body and accelerates recovery in post-ischemia, as well as promotes faster adaptation of physiological reserves to ischemic damage.

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