Pharmacological Correction of Physical Performance in Male Rats with Peptide Preparations when Changing the Lighting Regime
https://doi.org/10.33647/2713-0428-20-3E-129-134
Abstract
This study examined the effect of peptide extracts from the epiphysis-pituitary gland of reindeer (Rangifer tarandus) and delta-sleep-inducing peptide, simulating modified release, on the physical performance of male rats under conditions of light desynchronosis. All tested agents had a positive effect on the physical performance of male rats, increasing the duration of the first and second swim, depending on the lighting regime and the degree of desynchronization. In addition, the effectiveness of the tested agents was also noted after a course of intranasal administration (formed light desynchronosis), which indicates their prolonged action. This method of pharmacological tuning of the body’s circadian oscillators by agents of a peptide nature with a modified release can be used to develop a scheme for correcting light desynchronosis.
About the Authors
A. V. Sharabanov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Andrey V. Sharabanov
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
E. G. Batotsyrenova
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia;
Saint Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Ekaterina G. Batotsyrenova, Cand. Sci. (Biol.), Assoc. Prof.
192019, Saint Petersburg, Bekhtereva Str., 1;
194100, Saint Petersburg, Litovskaya Str., 2
V. A. Kashuro
Saint Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia;
Herzen Russian State Pedagogical University;
Saint Petersburg State University
Russian Federation
Russian Federation
Vadim A. Kashuro, Dr. Sci. (Med.), Assoc. Prof.
194100, Saint Petersburg, Litovskaya Str., 2;
191186, Saint Petersburg, Moika River Emb., 48;
199034, Saint Petersburg, Universitetskaya Emb., 7/9
M. T. Gasanov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Melik T. Gasanov, Cand. Sci. (Med.), Assoc. Prof.
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
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Review
For citations:
Sharabanov A.V., Batotsyrenova E.G., Kashuro V.A., Gasanov M.T. Pharmacological Correction of Physical Performance in Male Rats with Peptide Preparations when Changing the Lighting Regime. Journal Biomed. 2024;20(3E):129-134. (In Russ.) https://doi.org/10.33647/2713-0428-20-3E-129-134
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