Modeling of Hypobaric and Hemic Hypoxia
https://doi.org/10.33647/2713-0428-20-3E-147-150
Abstract
The mechanisms of hypoxia development at various levels – from molecular and cellular to organ and systemic – continue to attract research attention. At present, the pathogenetic demonstration of a new principle of pharmacological correction of metabolism and dysfunction in hypoxia seems relevant. In this work, hypobaric and hemic hypoxia is modeled, and the main markers for assessing the condition of animals are identified. Animals from the model group showed statistically significantly lower results in behavioral tests, which confirmed the success of modeling. The tested model and the markers for assessing the condition can be used to determine the antihypoxic effect of active medicinal substances.
About the Author
M. V. Shinelev
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences;
Pushchino Branch of the Russian Biotechnological University
Russian Federation
Russian Federation
Maxim V. Shinelev
142290, Moscow Region, Pushchino, Nauki Ave., 6;
142290, Moscow Region, Pushchino, Nauki Ave., 3
References
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Review
For citations:
Shinelev M.V. Modeling of Hypobaric and Hemic Hypoxia. Journal Biomed. 2024;20(3E):147-150. (In Russ.) https://doi.org/10.33647/2713-0428-20-3E-147-150
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