Development of Diabetic Neuropathy in C57BL/6 Mice in the Setting of a High-Fat Diet
https://doi.org/10.33647/2713-0428-20-3E-156-159
Abstract
Diabetic neuropathy in type 2 diabetes mellitus is one of the most common microvascular complications. Uncontrolled hyperglycemia leads to the formation of vascular abnormalities, eventually causing ischemia of nerve fibers. In our experiment, C57BL/6 mice were maintained on a high-fat diet for 21 weeks. At week 17, 19, and 21, blood glucose concentrations were measured; functional testing was performed using von Frey filaments, hot plate and limb cooling with acetone. In the present study, C57BL/6 mice on a high-fat diet showed increased sensitivity to mechanical stimulus, limb cooling and heating, which may indicate the development of diabetic polyneuropathy.
Supporting agencies: this work was supported by the Russian Science Foundation, grant No. 21-74-20147
About the Authors
N. A. Borozdina
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences;
Pushchino Branch of the Russian Biotechnological University
Russian Federation
Russian Federation
Natalya A. Borozdina
142290, Moscow Region, Pushchino, Nauki Ave., 6;
142290, Moscow Region, Pushchino, Nauki Ave., 3
I. N. Gladkikh
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Irina N. Gladkikh, Cand. Sci. (Chem.)
690041, Primorsky Krai, Vladivostok, 100 Let Vladivostoku Ave., 159
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Review
For citations:
Borozdina N.A., Gladkikh I.N. Development of Diabetic Neuropathy in C57BL/6 Mice in the Setting of a High-Fat Diet. Journal Biomed. 2024;20(3E):156-159. (In Russ.) https://doi.org/10.33647/2713-0428-20-3E-156-159
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