Taxifolin Antihypertensive Effect in an Age-Related Hypertension Model
https://doi.org/10.33647/2713-0428-20-3E-206-210
Abstract
This work shows that age-related arterial hypertension in Wistar rats develops with age, in 52% of 18-monthold animals versus 33% of 3-month-old animals. Effects of Taxifolin at a dose of 100 mg/kg, administered intraperitoneally for a week, on blood pressure (BP) and biochemical parameters in 18-month-old and 3-month-old animals were studied. The experimental animals were divided into two groups, those normotensive (BP<115 mmHg) and hypertensive (BP>115 mmHg). It was shown that a weekly course of Taxifolin leads to a significant decrease in blood pressure in hypertensive 18-month-old animals with no effect on blood pressure in normotensive animals. In addition, some age-related changes in the biochemical parameters of blood under the influence of Taxifolin were revealed.
About the Authors
N. A. Perepechenova
Pushchino Branch of the Russian Biotechnological University;
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Natalya A. Perepechenova
142290, Moscow Region, Pushchino, Nauki Ave., 3;
142290, Moscow Region, Pushchino, Nauki Ave., 6
E. A. Tukhovskaya
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elena A. Tukhovskaya, Cand. Sci. (Pharm.)
142290, Moscow Region, Pushchino, Nauki Ave., 6
A. M. Ismailova
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Alina M. Ismailova
142290, Moscow Region, Pushchino, Nauki Ave., 6
E. R. Shayhutdinova
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elvira R. Shayhutdinova, Cand. Sci. (Biol.)
142290, Moscow Region, Pushchino, Nauki Ave., 6
G. A. Slashcheva
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Gulsara A. Slashcheva, Cand. Sci. (Biol.)
142290, Moscow Region, Pushchino, Nauki Ave., 6
E. S. Sadovnikova
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elena S. Sadovnikova
142290, Moscow Region, Pushchino, Nauki Ave., 6
I. A. Dyachenko
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Igor A. Dyachenko, Dr. Sci. (Biol.), Assoc. Prof.
142290, Moscow Region, Pushchino, Nauki Ave., 6
A. N. Murashev
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Arkadiy N. Murashev, Dr. Sci. (Biol.), Prof.
142290, Moscow Region, Pushchino, Nauki Ave., 6
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Review
For citations:
Perepechenova N.A., Tukhovskaya E.A., Ismailova A.M., Shayhutdinova E.R., Slashcheva G.A., Sadovnikova E.S., Dyachenko I.A., Murashev A.N. Taxifolin Antihypertensive Effect in an Age-Related Hypertension Model. Journal Biomed. 2024;20(3E):206-210. (In Russ.) https://doi.org/10.33647/2713-0428-20-3E-206-210
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