Search for Effective Antibodies to Morphine Derivatives
https://doi.org/10.33647/2074-5982-21-2-17-26
Abstract
A scheme for immunization of goats with morphine derivatives conjugated with bovine serum albumin (BSA) is proposed. It was shown that antibodies to morphine are formed in high titers in blood serum (2×10–6) and goat milk (1×10–4). The specificity of antibodies to morphine was confirmed using ELISA and Western blot methods.
About the Authors
A. G. Berzina
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Asya G. Berzina, Cand. Sci. (Biol.)
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
D. K. Ismailova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Diana K. Ismailova
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
D. V. Khvostov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia ; V.M. Gorbatov Federal Research Center for Food Systems of the Russian Academy of Sciences
Russian Federation
Russian Federation
Daniil V. Khvostov, Cand. Sci. (Tech.)
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
109316, Moscow, Talalikhina Str., 26
M. A. Savina
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Maria A. Savina
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
N. N. Karkischenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Nikolay N. Karkischenko, Corr. Member of the Russian Academy of Sciences, Dr. Sci. (Med.), Prof.
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
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Review
For citations:
Berzina A.G., Ismailova D.K., Khvostov D.V., Savina M.A., Karkischenko N.N. Search for Effective Antibodies to Morphine Derivatives. Journal Biomed. 2025;21(2):17-26. (In Russ.) https://doi.org/10.33647/2074-5982-21-2-17-26
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