Metabolic, Blood Cell and Bone Marrow Status in db/db Mice Treated with Lactoferrin at Various Stages of Type 2 Diabetes Mellitus
https://doi.org/10.33647/2074-5982-21-3-47-52
Abstract
The use of Lactoferrin (Lf) for treating stages I and II of type 2 diabetes mellitus (DM2) initially stabilized the glucose level and weight of db/db mice, followed by normalization of these parameters after the drug discontinuation. By the end of Lf usage at stage III of DM2, these parameters in the animals sharply decreased, leading to their rapid death. In all experiments, under Lf treatment at stages I, II, and III of DM2, the oxidative metabolism index (OMI) was initially decreasing, followed by its growth to higher than the initial level at stages I and II of DM2 after the drug discontinuation, and was sharply decreasing again at stage III. The corresponding stress-adaptive changes were also revealed for blood cells and bone marrow, the development of which was carried out with the participation of programmed cell death mechanisms. Lf used to correct clinical manifestations of DM2 acts as a powerful adaptogen. It is capable of exerting an adjuvant effect on the metabolism and state of blood and bone marrow cells, but only at early stages with preserved adaptive reserves in the body.
Supporting agencies: the work was partially performed within the framework of the state assignment on the topic: “Assessment of the physiological balance of the body under the influence of extreme environmental factors” (No. FGFU-2025-0003)
About the Authors
O. I. Stepanova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Olga I. Stepanova - Cand. Sci. (Biol.).
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
R. A. Klesov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Roman A. Klesov
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
Kh. Kh. Semenov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Khyzyr Kh. Semenov - Cand. Sci. (Biol.).
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
N. A. Onishchenko
Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Nina A. Onishchenko - Dr. Sci. (Med.), Prof.
123182, Moscow, Shchukinskaya Str., 1
A. O. Nikolskaya
Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Alla O. Nikolskaya - Cand. Sci. (Biol.)
123182, Moscow, Shchukinskaya Str., 1
G. A. Puzyreva
Research Institute of General Pathology and Pathophysiology
Russian Federation
Russian Federation
Galina A. Puzyreva
125315, Moscow, Baltiyskaya Str., 8
I. B. Alchinova
Research Institute of General Pathology and Pathophysiology
Russian Federation
Russian Federation
Irina B. Alchinova - Cand. Sci. (Biol.)
125315, Moscow, Baltiyskaya Str., 8
M. S. Demorzhi
Research Institute of General Pathology and Pathophysiology
Russian Federation
Russian Federation
Marina S. Demorzhi
125315, Moscow, Baltiyskaya Str., 8
A. B. Cherepov
Research Institute of General Pathology and Pathophysiology
Russian Federation
Russian Federation
Anton B. Cherepov
125315, Moscow, Baltiyskaya Str., 8
A. A. Metelkin
Research Institute of General Pathology and Pathophysiology
Russian Federation
Russian Federation
Arkady A. Metelkin
125315, Moscow, Baltiyskaya Str., 8
M. V. Nesterenko
Lactobio LLC
Russian Federation
Russian Federation
Mikhail V. Nesterenko - Dr. Sci. (Biol.).
119331, Moscow, Vernadsky Ave., 29
Yu. B. Basok
Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Yulia B. Basok - Dr. Sci. (Med.).
123182, Moscow, Shchukinskaya Str., 1
References
1. Stepanova O.I., Klesov R.A., Semenov Kh. Kh., Pomytkin I.A., Onishchenko N.A., Karkischenko V.N. Sposob neinvazivnogo izucheniya tkanevyh narushenij pri saharnom diabete 2 tipa u myshej db/db c pomoshch'yu lazernoj dopplerovskoj fluometrii [A method for noninvasive studying tissue disorders in type 2 diabetes mellitus in db/db mice using laser Dopple Experimental Therapy]. 2023;67(2):118–129. (In Russian). DOI: 10.25557/00312991.2023.02.118-129.
Review
For citations:
Stepanova O.I., Klesov R.A., Semenov Kh.Kh., Onishchenko N.A., Nikolskaya A.O., Puzyreva G.A., Alchinova I.B., Demorzhi M.S., Cherepov A.B., Metelkin A.A., Nesterenko M.V., Basok Yu.B. Metabolic, Blood Cell and Bone Marrow Status in db/db Mice Treated with Lactoferrin at Various Stages of Type 2 Diabetes Mellitus. Journal Biomed. 2025;21(3):47-52. (In Russ.) https://doi.org/10.33647/2074-5982-21-3-47-52
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