Effect of Recombinant Myostatin Immunization on the Weight Gain of Lambs
https://doi.org/10.33647/2074-5982-21-3-58-62
Abstract
The development of biologically active drugs based on genetic engineering technologies is a promising area in the field of creating vaccines for livestock, in particular, to increase meat productivity in sheep farming. Myostatin is a negative regulator of skeletal muscle growth. Blocking the action of endogenous protein by immunizing animals with recombinant myostatin leads to the development of a specific antibody response and a gain in muscle mass. The effect of three-fold vaccination with recombinant myostatin on the weight gain of lambs (rams and sheep) during the fattening period under pasture–corral conditions was studied. It was shown that the weight gain of immunized rams and sheep during the period of 4.5 months was higher than that in the control group animals by an average of 4 and 2 kg, respectively. The absence of mortality in the experimental group was noted, suggesting a positive effect of E. coli impurity proteins in the recombinant vaccine.
Supporting agencies: the work was performed in the framework of State Project No. 0445-2021-0002 indicated only when available
About the Authors
V. A. Ezerskiy
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after Academician L.K. Ernst
Russian Federation
Russian Federation
Vadim A. Ezerskiy
249013, Kaluga Region, Borovsk, Institut Village
O. B. Zhukova
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after Academician L.K. Ernst
Russian Federation
Russian Federation
Olga B. Zhukova
249013, Kaluga Region, Borovsk, Institut Village
E. M. Koloskova
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after Academician L.K. Ernst
Russian Federation
Russian Federation
Elena M. Koloskova - Cand. Sci. (Biol.).
249013, Kaluga Region, Borovsk, Institut Village
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Review
For citations:
Ezerskiy V.A., Zhukova O.B., Koloskova E.M. Effect of Recombinant Myostatin Immunization on the Weight Gain of Lambs. Journal Biomed. 2025;21(3):58-62. (In Russ.) https://doi.org/10.33647/2074-5982-21-3-58-62
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