Biomodeling Remote Consequences of Acute Phenylcarbamate Poisoning
https://doi.org/10.33647/2074-5982-21-3-63-67
Abstract
Acute intoxications with pesticides, herbicides, and insecticides based on cholinesterase inhibitors account for up to 50% of hospitalizations due to toxic poisoning, leading to either long-term incapacitation or disability. These compounds predominantly cause dysfunction of the cholinergic mediator system, while exhibiting non-receptor effects. The consequences of severe carbamate poisoning can result in pathological conditions that occur in the long-term period of intoxication, including psycho-organic syndrome, asthenic conditions, neuropathies. The current literature lacks data on preventive or therapeutic drugs to prevent the occurrence of such conditions. The development of effective means of pharmacological correction requires adequate biomodels for studying remote effects of carbamate poisoning.
Supporting agencies: the scientific research was conducted within the framework of the State assignment of the Federal Medical and Biological Agency of Russia No. 388-00071-24-00 (topic code 64.004.24.800)
About the Authors
P. K. Potapov
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia; S.M. Kirov Military Medical Academy of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Petr K. Potapov - Cand. Sci (Med.)
192019, Saint Petersburg, Bekhtereva Str., 1; 194044, Saint Petersburg, Akad. Lebedeva Str., 6Zh
E. B. Shustov
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Evgeny B. Shustov - Dr. Sci. (Med.), Prof.
192019, Saint Petersburg, Bekhtereva Str., 1
M. V. Melnikova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Margarita V. Melnikova
192019, Saint Petersburg, Bekhtereva Str., 1
A. V. Belskaya
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Alisa V. Belskaya
192019, Saint Petersburg, Bekhtereva Str., 1
E. A. Zolotoverkhaia
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Ekaterina A. Zolotoverkhaya
192019, Saint Petersburg, Bekhtereva Str., 1
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Review
For citations:
Potapov P.K., Shustov E.B., Melnikova M.V., Belskaya A.V., Zolotoverkhaia E.A. Biomodeling Remote Consequences of Acute Phenylcarbamate Poisoning. Journal Biomed. 2025;21(3):63-67. (In Russ.) https://doi.org/10.33647/2074-5982-21-3-63-67
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