Biochemical Markers of Multiple Organ Failure (Organ Dysfunction) in Experimental Modeling of Internal Intestinal Fistulas
https://doi.org/10.33647/2074-5982-21-3-68-72
Abstract
In experiments on 20 rats, biochemical markers of organ dysfunction were assessed 6 and 24 h after modeling internal intestinal fistulas. It was found that biochemical markers of organ dysfunction allow early detection of impaired protein-synthetic function of the liver, development of cytolysis and cholestasis syndrome, and impaired renal function after modeling internal intestinal fistulas.
About the Authors
N. S. Tropskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department; Moscow Aviation Institute (National Research University)
Russian Federation
Russian Federation
Nataliya S. Tropskaya - Dr. Sci. (Biol.)
129090, Moscow, Bolshaya Sukharevskaya Sq., 3; 125993, Moscow, Volokolamskoe Highway, 4
E. V. Klychnikova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Elena V. Klychnikova - Cand. Sci. (Med.).
125993, Moscow, Volokolamskoe Highway, 4
E. A. Kislykova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Ekaterina A. Kislykova - Cand. Sci. (Biol.).
125993, Moscow, Volokolamskoe Highway, 4
I. G. Vilkova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Irina G. Vilkova
125993, Moscow, Volokolamskoe Highway, 4
O. S. Kislitsyna
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Oksana S. Kislitsyna
125993, Moscow, Volokolamskoe Highway, 4
Yu. V. Gurman
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Yulia V. Gurman
125993, Moscow, Volokolamskoe Highway, 4
O. V. Razbitskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Olga V. Razbitskaya
125993, Moscow, Volokolamskoe Highway, 4
A. Yu. Anurov
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Artem Yu. Anurov
125993, Moscow, Volokolamskoe Highway, 4
References
1. Dement'eva I.I., Kukaeva E.V. Sovremennye laboratornye biomarkery diagnostiki disfunkcij organov-mishenej pri sindrome poliorgannoj nedostatochnosti [Modern laboratory biomarkers for diagnostics of target organ dysfunctions in multiple organ failure syndrome]. Medicinskij alfavit. Seriya “Sovremennaya laboratoriya” [Medical alphabet. Series “Modern laboratory”]. 2019;1(4):37–42. (In Russian). DOI: 10.33667/2078-5631-2019-1-4(379)-37-42.
2. Lipatov V.A., Gavrilyuk V.P., Severinov D.A., Padalkina O.V. Modelirovanie perforacij v eksperimental'noj abdominal'noj hirurgii: obzor metodik i nash opyt [Modeling of perforations in experimental abdominal surgery: a review of methods and our experience]. Experimental and clinical gastroenterology. 2024;226(6):139–144. (In Russian). DOI: 10.31146/1682-8658-ecg-226-6-139-144.
3. Cherkasova M.N. K probleme eksperimental'nogo modelirovaniya sepsisa [On the problem of experimental modeling of sepsis]. Uspekhi sovremennoj biologii [Advances in modern biology]. 2021;141(4):368–381. (In Russian). DOI: 10.31857/S0042132421030054.
Review
For citations:
Tropskaya N.S., Klychnikova E.V., Kislykova E.A., Vilkova I.G., Kislitsyna O.S., Gurman Yu.V., Razbitskaya O.V., Anurov A.Yu. Biochemical Markers of Multiple Organ Failure (Organ Dysfunction) in Experimental Modeling of Internal Intestinal Fistulas. Journal Biomed. 2025;21(3):68-72. (In Russ.) https://doi.org/10.33647/2074-5982-21-3-68-72
Views:
8
Email this article 
