Hepatoprotective Properties of Choline Bitartrate in Piglets
https://doi.org/10.33647/2074-5982-21-3-107-112
Abstract
Various methionine metabolites used in the treatment of experimental liver diseases in animals demonstrate hepatoprotective properties. The prophylactic use of choline was shown to provide intensive liver regeneration. In this study, we aim to evaluate the hepatoprotective effects of choline bitartrate in piglets, with an assessment of cytokine expression associated with the hepatobiliary system. The research was conducted using experimental pigs reared at the age of 45 days, which corresponds to the period of their early development. The use of choline bitartrate significantly reduces the expression of β transforming growth factor (TGF-β1) and pro-inflammatory interleukin 6 (IL-6) genes, at the same time as providing a significant reduction in total cholesterol and a proportional increase in HDL concentration, which is a classical anti-atherogenic factor.
Supporting agencies: the work was carried out within the framework of the State assignment No. 124020200032-4 for 2023-2026
About the Author
K. S. Ostrenko
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after Academician L.K. Ernst
Russian Federation
Russian Federation
Konstantin S. Ostrenko - Dr. Sci. (Biol.).
249013, Kaluga Region, Borovsk, Institut Village
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Review
For citations:
Ostrenko K.S. Hepatoprotective Properties of Choline Bitartrate in Piglets. Journal Biomed. 2025;21(3):107-112. (In Russ.) https://doi.org/10.33647/2074-5982-21-3-107-112
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