Antianhedonic Effect of Ornithine Aspartate in Experimental Non-Alcoholic Steatohepatitis
https://doi.org/10.33647/2074-5982-21-3-113-116
Abstract
This study aimed to evaluate the potential antidepressant effect of ornithine aspartate (LOLA) (3 g/kg/day for 3 months) in mice with an alimentary/toxic model of non-alcoholic steatohepatitis (NASH) (n=70). Animals with NASH demonstrated a significantly decreased sucrose preference, which indicated the presence of food anhedonia. Treatment with LOLA provided a significant anti-anhedonic effect.
About the Authors
V. A. Prikhodko
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Veronika A. Prikhodko - Cand. Sci. (Biol.), Assoc. Prof.
197376, Saint Petersburg, Prof. Popova Str., 14A
A. S. Samarich
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Aleksey S. Samarich
197376, Saint Petersburg, Prof. Popova Str., 14A
T. M. Matuzok
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Tatyana M. Matuzok
197376, Saint Petersburg, Prof. Popova Str., 14A
U. V. Sharkova
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Ulyana V. Sharkova
197376, Saint Petersburg, Prof. Popova Str., 14A
K. S. Doroshchuk
S.M. Kirov Military Medical Academy of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Ksenia S. Doroshchuk
194044, Saint Petersburg, Akad. Lebedeva Str., 6Zh
M. O. Pyatchenkov
S.M. Kirov Military Medical Academy of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Mikhail O. Pyatchenkov - Cand. Sci. (Med.), Assoc. Prof.
194044, Saint Petersburg, Akad. Lebedeva Str., 6Zh
S. V. Okovitiy
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Sergey V. Okovitiy - Dr. Sci. (Med.), Prof.
197376, Saint Petersburg, Prof. Popova Str., 14A
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Review
For citations:
Prikhodko V.A., Samarich A.S., Matuzok T.M., Sharkova U.V., Doroshchuk K.S., Pyatchenkov M.O., Okovitiy S.V. Antianhedonic Effect of Ornithine Aspartate in Experimental Non-Alcoholic Steatohepatitis. Journal Biomed. 2025;21(3):113-116. (In Russ.) https://doi.org/10.33647/2074-5982-21-3-113-116
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