Approaches to Efficacy and Safety Assessment of Glucocorticosteroid Drugs in Experimental Acute Respiratory Distress Syndrome
https://doi.org/10.33647/2074-5982-21-3-117-121
Abstract
An experimental model of acute respiratory distress syndrome was used to determine the following easily reproducible parameters for assessing the efficacy and safety of various glucocorticosteroid therapy regimens: cell viability in bronchoalveolar lavage fluid, calculated values of air-blood barrier permeability index, as well as other routine cytological and biochemical indicators.
About the Authors
V. A. Pugach
State Scientific Research Testing Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Victoria A. Pugach - Cand. Sci. (Biol.), Assoc. Prof.
195043, Saint Petersburg, Lesoparkovaya Str., 4
N. I. Voloshin
S.M. Kirov Military Medical Academy of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Nikita I. Voloshin - Cand. Sci. (Med.)
194044, Saint Petersburg, Akad. Lebedeva Str., 6
P. A. Makhrachev
State Scientific Research Testing Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Pavel A. Makhrachev
194044, Saint Petersburg, Akad. Lebedeva Str., 6
M. A. Tyunin
State Scientific Research Testing Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Mikhail A. Tyunin - Cand. Sci. (Med.).
194044, Saint Petersburg, Akad. Lebedeva Str., 6
E. A. Suvorova
State Scientific Research Testing Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Eugenia A. Suvorova
194044, Saint Petersburg, Akad. Lebedeva Str., 6
K. I. Taborskaya
State Scientific Research Testing Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Ksenia I. Taborskaya
194044, Saint Petersburg, Akad. Lebedeva Str., 6
V. V. Salukhov
S.M. Kirov Military Medical Academy of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Vladimir V. Salukhov - Dr. Sci. (Med.), Prof.
194044, Saint Petersburg, Akad. Lebedeva Str., 6
References
1. Pugach V.A., Tyunin M.A., Ilinskiy N.S., Levchuk E.V., Strokina E.I., Eltsov A.A. Eksperimental'naya model' pryamogo ostrogo povrezhdeniya legkih u krys, vyzvannogo intratraheal'nym vvedeniem lipopolisaharida Salmonella enterica [An experimental model of direct acute lung injury in rats caused by intratracheal administration of lipopolysaccharide from Salmonella enterica]. Biomeditsina [Journal Biomed]. 2021;17(3):84–89. (In Russian). DOI: 10.33647/2074-5982-17-3-84-89.
2. Jayasimhan D., Matthay M.A. Corticosteroids in adults with acute respiratory distress syndrome and severe pneumonia. BJA Educ. 2023;23(12):456–463. DOI: 10.1016/j.bjae.2023.08.00.
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Review
For citations:
Pugach V.A., Voloshin N.I., Makhrachev P.A., Tyunin M.A., Suvorova E.A., Taborskaya K.I., Salukhov V.V. Approaches to Efficacy and Safety Assessment of Glucocorticosteroid Drugs in Experimental Acute Respiratory Distress Syndrome. Journal Biomed. 2025;21(3):117-121. (In Russ.) https://doi.org/10.33647/2074-5982-21-3-117-121
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