Effects of lepr Editing in Rabbits (Oryctolagus cuniculus)
https://doi.org/10.33647/2074-5982-21-4-22-26
Abstract
The CRISPR/Cas gene editing method and reproductive biotechnologies were used to create rabbits with a knockout of the gene for the receptor of the systemic regulator of lipid metabolism – leptin (lepr). Studies performed with clinical laboratory and functional diagnostics provided data on physiologic parameters and revealed some effects of lepr editing in the domestic rabbit. The results suggest that domestic rabbits with lepr knockout may serve as a biomedical model of morbid obesity and metabolic disorders caused by mutations in the leptin receptor gene.
Supporting agencies: the study was performed within the framework of the State assignment under the R&D topic No. FGGR-2024-0004. Acknowledgments: the work was carried out with the use of LSRF “Collection of gene edited rabbits’ lines”.
About the Authors
D. V. Popov
V.A. Afanasyev Research Institute of Fur Farming and Rabbit Breeding
Russian Federation
Russian Federation
Dmitry V. Popov, Cand. Sci. (Biol.)
140143, Moscow Region, Ramenskiy District, Rodniki Village, Trudovaya Str., 6
O. I. Skobel
V.A. Afanasyev Research Institute of Fur Farming and Rabbit Breeding
Russian Federation
Russian Federation
Olga I. Skobel
140143, Moscow Region, Ramenskiy District, Rodniki Village, Trudovaya Str., 6
D. E. Vysotskii
V.A. Afanasyev Research Institute of Fur Farming and Rabbit Breeding
Russian Federation
Russian Federation
Denis E. Vysotskii
140143, Moscow Region, Ramenskiy District, Rodniki Village, Trudovaya Str., 6
G. Yu. Kosovsky
V.A. Afanasyev Research Institute of Fur Farming and Rabbit Breeding
Russian Federation
Russian Federation
Gleb Yu. Kosovsky, Dr. Sci. (Biol.), Corr. Member of the Russian Academy of Sciences
140143, Moscow Region, Ramenskiy District, Rodniki Village, Trudovaya Str., 6
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Review
For citations:
Popov D.V., Skobel O.I., Vysotskii D.E., Kosovsky G.Yu. Effects of lepr Editing in Rabbits (Oryctolagus cuniculus). Journal Biomed. 2025;21(4):22-26. (In Russ.) https://doi.org/10.33647/2074-5982-21-4-22-26
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