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Mapping the Psychoemotional State of Animals and Effects of Psychotropic Drugs Based on Ultrasonic Vocalization Parameters

https://doi.org/10.33647/2074-5982-21-4-27-38

Abstract

The phenomenon of ultrasonic vocalization (USV) is characteristic of various laboratory animals, which are widely used in biomedical research. This phenomenon is closely linked to the functional state of animals’ central nervous system, their psychoemotional status, response to extreme stimuli, and the processes of zoosocial communication. These characteristics have allowed the introduction of USV research methods into biomedical research aimed at modeling various diseases, pathological and sanogenetic processes, and evaluating the efficacy of psychopharmacological agents. In this article, we set out to investigate the possibility of identifying the characteristics of the psychophysical state of laboratory animals using USV. A matrix for identifying the emotional states of rats based on spectral analysis of their USV is presented.

About the Authors

N. N. Karkischenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

Nikolay N. Karkischenko, Dr. Sci. (Med.), Prof., Academician of the Russian Academy of Rocket and Artillery Sciences, Corresponding Member of the Russian Academy of Sciences

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



Yu. V. Fokin
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

Yuriy V. Fokin, Cand. Sci. (Biol.)

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



E. B. Shustov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia; Scientific and Clinical Center of Toxicology named after S.N. Golikov of the Federal Medical and Biological Agency of Russia
Russian Federation

Evgeny B. Shustov, Dr. of Sci. (Med.), Prof.

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1

192019, St. Petersburg, Bekhterev Str., 1



References

1. Gavrilov V.V. Kooperaciya i ul`trazvukovaya kommunikaciya u krys [Cooperation and ultrasonic communication in rats]. Kognitivnye issledovaniya [Cognitive studies]. Iss. 7. Ed. by D.V. Ushakov, A.A. Medyntsev. Moscow: IP RAN Publ. 2017:81–91. (In Russian)].

2. Gasanov M.T., Fokin Yu.V., Lyublinskiy S.L., Alimkina O.V., Taboyakova L.A., Karkischenko V.N. Doklinicheskie issledovaniya effektivnosti i bezopasnosti kompleksa biologicheski aktivnyh veshchestv, vydelennyh iz muskusa kabargi sibirskoj, v liposomirovannoj lekarstvennoj forme [Preclinical studies of the efficacy and safety of a complex of biologically active substances isolated from Siberian musk deer musk in liposomal dosage form]. Biomedicina [Journal Biomed]. 2022;18(4):48–62. (In Russian)].

3. Gromova D.S., Pavlova O.N., Myakisheva Yu.V., Popova N.R. Obzor podhodov k modelirovaniyu rasstrojstv autisticheskogo spektra u zhivotnyh i izuchenie effektivnosti modelej v biomedicinskih issledovaniyah (obzor problemy) [Review of approaches to modeling autism spectrum disorders in animals and studying the effectiveness of models in biomedical research (review of the problem)]. Laboratornye zhivotnye dlya nauchnyh issledovanij [Laboratory animals for scientific research]. 2024;4:14–21. (In Russian)].

4. ZapekinS.G., Shaposhnikov K.V., Suslov N.I., Kulpin P.V., Fedorova Yu.S. Preimushchestva metodiki registracii ul`trazvukovyh vokalizacij pri issledovanii anksioliticheskoj aktivnosti farmakologicheskih substancij [Advantages of the method of recording ultrasonic vocalizations in the study of the anxiolytic activity of pharmacological substances]. Aktual`nye voprosy fundamental`noj i klinicheskoj mediciny [Current issues in fundamental and clinical medicine]. Sb. mat-lov kongressa molodyh uchenyh [Collection of materials of the congress of young scientists]. Tomsk, 2020:485–489. (In Russian)].

5. Karkischenko V.N., Fokin Yu.V., Chayvanov D.B., Chudina Yu.A., Nikolaev A.A. Vliyanie transkranial`noj nizkochastotnoj elektrostimulyacii golovnogo mozga na spektral`nye harakteristiki ul`trazvukovoj vokalizacii mini-svinej svetlogorskoj populyacii [The influence of transcranial low-frequency electrical stimulation of the brain on the spectral characteristics of ultrasonic vocalization of minipigs of the Svetlogorsk population]. Biomedicina [Journal Biomed]. 2015;3:20–26. (In Russian)].

6. Karkischenko V.N., Fokin Yu.V., Shustov E.B. Analiz povedencheskih harakteristik i ul`trazvukovoj vokalizacii laboratornyh krys pri farmakologicheskoj korrekcii ix psihoemocional`nogo sostoyaniya [Analysis of behavioral characteristics and ultrasonic vocalization of laboratory rats during pharmacological correction of their psychoemotional state]. Biomedicina [Journal Biomed]. 2015;3:33–42. (In Russian)].

7. Karkischenko N.N. Osnovy biomodelirovaniya [Fundamentals of biomodeling]. Moscow: Izd-vo VPK, 2004:607. (In Russian)].

8. Karkischenko N.N. Psihounitropizm lekarstvennyh sredstv [Psychounitropism of drugs]. Moscow: Medicina Publ., 1993:208. (In Russian)].

9. Karkischenko N.N., Fokin Yu.V., Karkischenko V.N., Sakharov D.S., Alimkina O.V. Rol` nejromediatornyh sistem mozga v generacii ul`trazvukovoj vokalizacii i ee korrelyacii s povedeniem zhivotnyh [The role of neurotransmitter systems of the brain in the generation of ultrasonic vocalization and its correlation with animal behavior]. Biomedicina [Journal Biomed]. 2011;4:8–18. (In Russian)].

10. Karkischenko N.N., Fokin Yu.V., Nikolaev A.A., Chudina Yu.A., Chayvanov D.B., Emelyanova A.E. Informativnye parametry ul`trazvukovoj vokalizacii krolikov pri vysoko- i nizkochastotnoj transkranial`noj elektrostimulyacii [Informative parameters of ultrasonic vocalization of rabbits during high- and low-frequency transcranial electrical stimulation]. Biomedicina [Journal Biomed]. 2017;4:46–52. (In Russian)].

11. Karkischenko N.N., Fokin Yu.V., Sakharov D.S., Karkischenko V.N., Kapanadze G.D., Chaivanov D.B. Ul`trazvukovaya vokalizaciya i ee informativnye parametry u zhivotnyh i cheloveka [Ultrasonic vocalization and its informative parameters in animals and humans]. Biomedicina [Journal Biomed]. 2011;1:4–23. (In Russian)].

12. Karkischenko N.N., Chayvanov D.B., Fokin Yu.V. Rekomendacii po ustraneniyu shumov pri zapisi parametrov ul`trazvukovoj vokalizacii zhivotnyh i cheloveka [Recommendations for eliminating noise when recording ultrasonic vocalization parameters of animals and humans]. Vestnik psihofiziologii [Bulletin of Psychophysiology]. 2012;1:45-47. (In Russian)].

13. Lupanova A.S. Sravnitel`nyj analiz vokalizacij dikih i linejnyh domovyh myshej (Mus musculus) [Comparative analysis of vocalizations of wild and linear house mice (Mus musculus)]. Acoustic journal. 2024;70(S5):54. (In Russian)].

14. Muzyko E.A., Lukina A.S., Karelina D.A., Tarasov A.S., Perfilova V.N., Frolov E.M., Frolov M. Yu. Issledovanie povedencheskih reakcij i dlitel`nosti ul`trazvukovoj vokalizacii u krysyat ot stressirovannyh v period beremennosti samok [Study of behavioral reactions and duration of ultrasonic vocalization in rat pups from females stressed during pregnancy]. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(3):117–123. (In Russian)].

15. Nesterova Yu.V., Vsyakikh O.V., Kulpin P.V., Povetyeva T.N., Zyuzkov G.N., Suslov N.I., Zhdanov V.V., Losev E.A. Sravnitel`noe issledovanie anksioliticheskoj aktivnosti zongorina v pripodnyatom krestoobraznom labirinte i metodom registracii ul`trazvukovyh vokalizacij [Comparative study of the anxiolytic activity of songorine in the elevated plus maze and by recording ultrasonic vocalizations]. Bulletin of Experimental Biology and Medicine. 2024;177(5):612–616. (In Russian)].

16. Pyavchenko G.A., Uryvaev Yu.V., Nozdrin V.I. Sovmestnoe primenenie kompleksov LABORAS i SONOTRACK pri issledovanii povedencheskih reakcij u krys [Combined use of the LABORAS and SONOTRACK systems in studying behavioral responses in rats]. Uchenye zapiski Orlovskogo gosudarstvennogo universiteta. Ser.: Estestvennye, tehnicheskie i medicinskie nauki [Scientific Notes of Oryol State University. Series: Natural, Technical and Medical Sciences]. 2013;6:238–242. (In Russian)].

17. Riga V.D., Rebik A.A., Smirnov K.S., Sysoeva O.V., Midzyanovskaya I.S. Ul`trazvukovaya vokalizaciya kak marker narushenij zoosocial`nogo vzaimodejstviya u krys [Ultrasonic vocalization as a marker of disturbances in zoosocial interaction in rats]. Sb. tezisov XXVI nauchnoj shkolykonferencii molodyh uchenyh po fiziologii vysshej nervnoj deyatel`nosti i nejrofiziologii [Collection of abstracts of the XXVI scientific school-conference of young scientists on the physiology of higher nervous activity and neurophysiology]. Moscow, 2022:257261. (In Russian)].

18. Sitnikova E.Yu. Ul`trazvukovaya vokalizaciya laboratornyh krys kak novyj istochnik informacii dlya eksperimentatora [Ultrasonic vocalization of laboratory rats as a new source of information for the experimenter]. Nelinejnaya dinamika v kognitivnyh issledovaniyah [Nonlinear dynamics in cognitive research]. Trudy VIII Vseross. konf. [Proceedings of the VIII All-Russian Conf.]. Nizhny Novgorod, 2023:146–147. (In Russian)].

19. Fokin Yu.V. Primenenie analiza ul`trazvukovoj vokalizacii laboratornyh zhivotnyh v biomedicinskih i doklinicheskih issledovaniyah [Application of Ultrasonic Vocalization Analysis of Laboratory Animals in Biomedical and Preclinical Research]. Abstract of Dissertation … Cand. Sci. (Biol.). Moscow: NII normal`noj fiziologii im. P.K. Anohina RAMN Publ., 2014:28. (In Russian)].

20. Fokin Yu.V., Berzina A.G., Karkischenko V.N., Alimkina O.V., Gamaleya N.B. Vliyanie raznyh doz etanola na ul`trazvukovuyu vokalizaciyu krys [Effect of different doses of ethanol on ultrasonic vocalization of rats]. Biomedicina [Journal Biomed]. 2015;1:45–53. (In Russian)].

21. Fokin Yu.V., Karkischenko V.N. Vokalizaciya krys v ul`trazvukovom diapazone kak model` ocenki stressovogo vliyaniya obezdvizhivaniya, elektrokozhnogo razdrazheniya, fizicheskoj nagruzki i farmakodinamiki lekarstv [Vocalization of rats in the ultrasonic range as a model for assessing the stressful effect of immobilization, electrocutaneous stimulation, physical activity and pharmacodynamics of drugs]. Biomedicina [Journal Biomed]. 2010;5:17–21. (In Russian)].

22. Knutson B., Burgdorf J., Panksepp J. Ultrasonic vocalizations as indices of affective states in rats. Psychol. Bull. 2002;128:961–977.

23. Liu Ya., Cotton J.A., Shen B., Han X., Rossiter S.J., Zhang Sh. Convergent sequence evolution between echolocating bats and dolphins. Current Biology. 2010;20(2):R53–R54.

24. Panksepp J., Burgdorf J. “Laughing“ rats and the evolutionary antecedents of human joy? Physiology and Behavior. 2003;79:533–547.

25. Portfors C.V. Types and functions of ultrasonic vocalizations in laboratory rats and mice. J. Am. Ass. Lab. An. Sci. 2007;46(1):28–34.

26. Sanchez C. Stress-induced vocalization in adult animals. A valid model of anxiety? Eur. J. Pharmacol. 2003;28(463(1–3)):133–143.

27. Wöhr M., Borta A., Schwarting R.K.W. Overt behavior and ultrasonic vocalization in fear conditioning paradigm: A dose-response study in the rat. Neurobio Learn Mem. 2005;84:228–240.

28. Zippelius H.M., Schleidt W.M. Ultraschall-Laute bei jungen Mäusen. Naturwissenschaften. 1956;43:502.


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For citations:


Karkischenko N.N., Fokin Yu.V., Shustov E.B. Mapping the Psychoemotional State of Animals and Effects of Psychotropic Drugs Based on Ultrasonic Vocalization Parameters. Journal Biomed. 2025;21(4):27-38. (In Russ.) https://doi.org/10.33647/2074-5982-21-4-27-38

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