Changes in Blood System Parameters in Mouse Modeling of Long-Term Hypokinesia
https://doi.org/10.33647/2074-5982-21-4-39-43
Abstract
In this study, we evaluate the main hematological parameters and subfractional composition of mouse blood serum when modeling long-term hypokinesia. Hypokinesia was induced by placing the animal in a special glass and its fixation by the tail for 14 days. Hematological parameters were determined by a hematological analyzer; the subfractional composition of the serum were studied by laser correlation spectroscopy. Following 14-day hypokinesia, mice showed a significant increase in the number of neutrophils and a decrease in the number of lymphocytes. A significant increase in the number of circulating erythrocytes was also detected. The subfractional composition of mouse blood serum after hypokinesia was distinguished by a significant increase in the contribution to light scattering of particles with a radius of 91.26 to 165.57 nm. Modeling long-term hypokinesia in laboratory animals is essential for developing approaches to the prevention and treatment of the consequences of decreased motor activity.
Supporting agencies: the work was carried out within the framework of the state assignment FGFU-2025-0003 “Assessment of the physiological balance of the body under the influence of extreme environmental factors” of the Research Institute of General Pathology and Pathophysiology.
About the Authors
I. B. Alchinova
Research Institute of General Pathology and Pathophysiology
Россия
Россия
Irina B. Alchinova, Cand. Sci. (Biol.)
125315, Moscow, Baltiyskaya Str., 8
M. V. Polyakova
Research Institute of General Pathology and Pathophysiology
Россия
Россия
Margarita V. Polyakova, Cand. Sci. (Biol.)
125315, Moscow, Baltiyskaya Str., 8
F. A. Sadovnikov
Research Institute of General Pathology and Pathophysiology
Россия
Россия
Fedor A. Sadovnikov
125315, Moscow, Baltiyskaya Str., 8
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Review
For citations:
Alchinova I.B., Polyakova M.V., Sadovnikov F.A. Changes in Blood System Parameters in Mouse Modeling of Long-Term Hypokinesia. Journal Biomed. 2025;21(4):39-43. (In Russ.) https://doi.org/10.33647/2074-5982-21-4-39-43
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