Effect of Choline Bitartrate on the Gut Microbiota of Piglets
https://doi.org/10.33647/2074-5982-21-4-44-48
Abstract
Oxidative stress (OS) associated with inflammatory processes affects the intestinal microbiota. Choline can act as a methyl donor and reduce the level of glutathione in the brain, inhibiting the development of OS and inflammatory processes. In turn, this contributes to prevention of dysbiotic disorders. In this work, we study the effect of choline bitartrate (CB) on the microbiota of the large intestine of pigs during the period of intensive growth. CB introduced as part of the main diet was found to affect the qualitative and quantitative composition of the microbiota. Thus, the proportion of normoflora increased, while the proportion and representation of pathogenic and opportunistic microorganisms decreased. CB contributed to the work of microorganisms secreting metabolites with high neurotransmitter activity and led to an increase in the proportion of phylum producers of lactate, an activator of intestinal macrophages.
Supporting agencies: the work was performed within the framework of the state assignment No. 124020200032-4.
About the Authors
N. V. Belova,
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Centre of Animal Husbandry — All-Russian Institute of Animal Husbandry named after Acad. L.K. Ernst
Russian Federation
Russian Federation
Nadezhda V. Belova, Cand. Sci. (Biol.)
249013, Kaluga Region, Borovsk, Institute Village
K. S. Ostrenko
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Centre of Animal Husbandry — All-Russian Institute of Animal Husbandry named after Acad. L.K. Ernst
Russian Federation
Russian Federation
Konstsntin S. Ostrenko, Dr. Sci. (Biol.)
249013, Kaluga Region, Borovsk, Institute Village
E. M. Koloskova
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Centre of Animal Husbandry — All-Russian Institute of Animal Husbandry named after Acad. L.K. Ernst
Russian Federation
Russian Federation
Elena M. Koloskova, Cand. Sci. (Biol.)
249013, Kaluga Region, Borovsk, Institute Village
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Review
For citations:
Belova, N.V., Ostrenko K.S., Koloskova E.M. Effect of Choline Bitartrate on the Gut Microbiota of Piglets. Journal Biomed. 2025;21(4):44-48. (In Russ.) https://doi.org/10.33647/2074-5982-21-4-44-48
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