Synaptic Efficacy of Hippocampal Neuronal Networks Due to Neuraminidase Inhibition
https://doi.org/10.33647/2074-5982-21-4-77-81
Abstract
Alterations in neuraminidase activity can significantly affect neuronal processes. In our previous work, we demonstrated the formation of new synapses as a result of neuraminidase blockage. In the present study, we analyzed the effect of reduced endogenous neuraminidase activity on the synaptic efficacy of newly formed hippocampal synapses. Preincubation of slices with the N-acetyl-2,3-dehydro-2-deoxyneuraminic acid (NADNA) specific inhibitor resulted in a significant increase in the amplitude of synaptic responses, accompanied by reduced variability and a leftward shift of the input–output curves, suggesting an enhancement of excitatory connectivity within the CA3-to-CA1 hippocampal network.
Supporting agencies: the study was conducted within the state assignment of the Ministry of Education of the Russian Federation (No. OTGE-2025-0019, Registration Code 1024122400023-5-5.3.1) and as part of research program No. AAAA-A21-121011990099-6.
About the Authors
A. V. Savotchenko
P.D. Osipenko Azov State Pedagogical University
Russian Federation
Russian Federation
Alina V. Savotchenko, Cand. Sci. (Biol.)
271118, Zaporozhie Region, Berdyansk, Svobody Str., 101/1
P. A. Galenko-Yaroshevsky
Kuban State Medical University
Russian Federation
Russian Federation
Pavel A. Galenko-Yaroshevsky, Dr. Sci. (Med.), Corr. Member of the RAS
350063, Krasnodar Krai, Krasnodar, Sedina Str., 4
E. N. Chuyan
V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Elena N. Chuyan, Dr. Sci. (Biol.), Prof.
295007, Crimea Republic, Simferopol, Vernadsky Ave., 4
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Review
For citations:
Savotchenko A.V., Galenko-Yaroshevsky P.A., Chuyan E.N. Synaptic Efficacy of Hippocampal Neuronal Networks Due to Neuraminidase Inhibition. Journal Biomed. 2025;21(4):77-81. (In Russ.) https://doi.org/10.33647/2074-5982-21-4-77-81
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