Modified Stress-Protective Effect of Hydroxyzine in Broiler Chickens at High Stocking Density
https://doi.org/10.33647/2074-5982-21-4-119-124
Abstract
An experiment on broiler chickens of the Smena-9 cross was conducted to study the effect of hydroxyzine, an anxiolytic, and its complex with ascorbic acid on the leukocyte profile under technological stress, namely an increase in stocking density. An increase in this indicator by 1.5 times in chickens during the period of intensive growth was found to trigger an extreme stress reaction, which is accompanied by changes in the blood system. The quantitative content of leukocytes and the percentage of five leukocyte subpopulations were determined. To assess stress-induced changes in morphological parameters, internal organs were weighed. An increase in stocking density led to changes in white blood cell parameters and an increase in the relative mass of the heart, liver, and kidneys. A trend towards a decrease in relative leukocytosis was revealed when using hydroxyzine both separately and together with ascorbic acid. The combined use of the studied preparations slightly shifts the indices (lymphocyte, leukocyte shift, immunoreactivity, condition index) to the values of the control group. The use of hydroxyzine and vitamin C reduces the relative weight of the heart, lungs, and liver. The conclusion is made about the positive effect of the combined use of the studied preparations on adaptation mechanisms, by mobilizing resistant mechanisms and influencing the functional activity of vegetative organs.
About the Authors
D. A. Ksenofontov
Russian State Agrarian University — Moscow Timiryazev Agricultural Academy
Russian Federation
Russian Federation
Dmitriy A. Ksenofontov, Dr. Sci. (Biol.), Assoc. Prof.
127434, Moscow, Timiryazevskaya Str., 49
E. A. Muradyan
Russian State Agrarian University — Moscow Timiryazev Agricultural Academy
Russian Federation
Russian Federation
Ekaterina А. Muradyan
127434, Moscow, Timiryazevskaya Str., 49
A. A. Ksenofontova
Russian State Agrarian University — Moscow Timiryazev Agricultural Academy
Russian Federation
Russian Federation
Anzhelika A. Ksenofontova, Cand. Sci. (Biol.), Assoc. Prof.
127434, Moscow, Timiryazevskaya Str., 49
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Review
For citations:
Ksenofontov D.A., Muradyan E.A., Ksenofontova A.A. Modified Stress-Protective Effect of Hydroxyzine in Broiler Chickens at High Stocking Density. Journal Biomed. 2025;21(4):119-124. (In Russ.) https://doi.org/10.33647/2074-5982-21-4-119-124
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