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Endocrine Mechanisms of the Adaptogenic Action of Lithium Ascorbate During Gestation

https://doi.org/10.33647/2074-5982-21-4-125-128

Abstract

Stress during gestation has a complex impact on the maternal organism and fetal development, leading to long-term changes in the neurophysiology and metabolism of offspring. The aim of this study was to evaluate the adaptogenic potential of lithium ascorbate in correcting stress responses in pregnant sows. The results demonstrate a pronounced modulatory effect of the studied compound on the hypothalamic- pituitary-adrenal (HPA) axis. The data obtained indicate the potential of lithium ascorbate for the prevention of stress-associated reproductive dysfunctions, thus suggesting new possibilities for managing stress reactivity during gestation.

About the Author

I. V. Kytin
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — Branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after Academician L.K. Ernst
Russian Federation

Ivan V. Kytin

249013, Kaluga Region, Borovsk, Institut Village



References

1. Karkischenko V.N., Semenov Kh.Kh., Karkischenko N.N. Vliyanie ostroy gipobaricheskoy gipoksii na reproduktivnuyu funktsiyu laboratornykh krys i myshey: soobshchenie 3. Issledovanie posledstviy ostroy gipobaricheskoy gipoksii na muzhskie reproduktivnye kletki krys i myshey [The Effect of Acute Hypobaric Hypoxia on Reproductive Function of Laboratory Rats and Mice: Report 3. Study of the Consequences of Acute Hypobaric Hypoxia on Male Reproductive Cells of Rats and Mice]. Biomeditsina [Journal Biomed]. 2015;(1):60–65. (In Russian)].

2. Bale T.L., Baram T.Z., Brown A.S., et al. Early life programming and neurodevelopmental disorders. Biol. Psychiatry. 2010;68(4):314–319. DOI: 10.1016/j.biopsych.2010.05.

3. Dahlerup B.R., Egsmose E.L., Siersma V., et al. Mater- nal stress and placental function, a study using questionnaires and biomarkers at birth. PLoS One 2018;13(11):e0207184. DOI: 10.1371/journal.pone.0207184.

4. Ostrenko K., Nekrasov R., Ovcharova A., Lemiasheuski V., Kutin I. The Effect of Lithium Salt with Ascorbic Acid on the Antioxidant Status and Productivity of Gestating Sows. Animals (Basel) 2022;12(7):915. DOI: 10.3390/ani12070915.

5. Panossian A., Wikman G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity. Pharmaceuticals (Basel). 2010;3(1):188–224. DOI: 10.3390/ph3010188.

6. Pearlstein T. Perinatal depression: treatment options and dilemmas. J. Psychiatry Neurosci 2008;33(4):302–318.


Review

For citations:


Kytin I.V. Endocrine Mechanisms of the Adaptogenic Action of Lithium Ascorbate During Gestation. Journal Biomed. 2025;21(4):125-128. (In Russ.) https://doi.org/10.33647/2074-5982-21-4-125-128

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ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)