Passive Avoidance in Adult and Middle-Aged Male C57BL/6 Mice after Intranasal α-Synuclein Administration
https://doi.org/10.33647/2074-5982-21-4-143-147
Abstract
A comparative study of the effects of α-synuclein species (monomers, oligomers or fibrils alone or in combination) administered intranasally for 14 days on passive avoidance in adult (3–7 months) and middle-aged (10–13 months) male C57BL/6 mice was conducted. Middle-aged mice treated with a solution of α-synuclein fibrils and oligomers were found to have a reduced latency to entry in the dark compartment during acquisition phase compared to controls (р<0.05). None of the experimental groups showed any impairment in long-term memory 24 h after training. The data obtained can be used in modeling human neurodegenerative diseases in animals.
About the Authors
O. A. Solovieva
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Olga A. Solovieva
125315, Moscow, Baltiyskaya Str., 8
N. P. Mikhaylova
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Nataliya P. Mikhaylova
125315, Moscow, Baltiyskaya Str., 8
M. A. Gruden
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Marina А. Gruden, Cand. Sci. (Chem.)
125315, Moscow, Baltiyskaya Str., 8
V. V. Sherstnev
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Vladimir V. Sherstnev, Dr. Sci. (Med.), Prof.
125315, Moscow, Baltiyskaya Str., 8
Z. I. Storozheva
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Zinaida I. Storozheva, Dr. Sci. (Biol.)
125315, Moscow, Baltiyskaya Str., 8
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Review
For citations:
Solovieva O.A., Mikhaylova N.P., Gruden M.A., Sherstnev V.V., Storozheva Z.I. Passive Avoidance in Adult and Middle-Aged Male C57BL/6 Mice after Intranasal α-Synuclein Administration. Journal Biomed. 2025;21(4):143-147. (In Russ.) https://doi.org/10.33647/2074-5982-21-4-143-147
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