Prospects for Using Oxygen–Helium Mixtures for Prevention and Restoration of Functions after Cerebral Ischemia
https://doi.org/10.33647/2074-5982-21-4-148-152
Abstract
Ischemic stroke remains one of the main causes of disability, which requires the search for improved methods of its prevention. In this study, the effectiveness of a hyperoxic oxygen–helium mixture in preventing brain damage during ischemia in Sprague Dawley rats was studied. The blood gas composition, the concentration of 2,3-diphosphoglycerate in erythrocytes, and functional indices were assessed. The results showed that oxygen–helium mixtures exhibit a pronounced protective effect in ischemic stroke, improving tissue oxygenation and reducing neurological deficit.
About the Author
A. V. Kholina
Pushchino Branch of the Russian Biotechnological University; Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Arina V. Kholina
142290, Moscow Region, Pushchino, Nauki Ave., 3
142290, Moscow Region, Pushchino, Nauki Ave., 6
References
1. Klochikhina O.A., Shprakh V.V., Stakhovskaya L.V., Polunina E.A. Analiz srednemnogoletnei zabolevaemosti i smertnosti ot insulta v regionakh Rossiiskoi Federatsii, voshedshikh v federalnuyu programmu reorganizatsii pomoshchi patsientam s insultom [Analysis of average long-term incidence and mortality from stroke in the regions of the Russian Federation included in the federal program for reorganization of care for patients with stroke]. S.S. Korsakov Journal of Neurology and Psychiatry. Special issues. 2020;120(12-2):37–41. (In Russian)].
2. Manuilov V.M., Suvorov A.V., Kurkin S.V., Olenev Yu.O., Pavlov N.B., Logunov A.T., Anikeev D.A., Orlov O.I. Otsenka effektivnosti kislorodno-gelievoi terapii u bolnykh s COVID-19 assotsiirovannoi pnevmoniei [Evaluation of the effectiveness of oxygen-helium therapy in patients with COVID-19 associated pneumonia] Aviakosmicheskaya i ekologicheskaya meditsina [Aerospace and Environmental Medicine]. 2021;55(1):51–58. (In Russian)]. DOI: 10.21687/0233-528X-2021-55-1-51-58.
3. Starodubtseva O.S., Begicheva S.V. Analiz zabolevaemosti insultom s ispolzovaniem informatsionnykh tekhnologii [Analysis of stroke incidence using information technologies]. Fundamentalnye issledovaniya [Fundamental research]. 2012;8(part 2):424–427. (In Russian)].
4. Ferrari A.J., et al. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted lifeyears (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet. 2023;403(10440):2133–2161.
Review
For citations:
Kholina A.V. Prospects for Using Oxygen–Helium Mixtures for Prevention and Restoration of Functions after Cerebral Ischemia. Journal Biomed. 2025;21(4):148-152. (In Russ.) https://doi.org/10.33647/2074-5982-21-4-148-152
Views:
7
Email this article 
