Multitarget Anti-Inflammatory Action of the Opioid Peptide Leytragin
https://doi.org/10.33647/2074-5982-22-1-10-14
Abstract
This study is the first to demonstrate that Leytragin reduces the protein expression of several pro-nflammatory cytokines—IL-1β, IL-6, and TNF-α—during the resolution phase of inflammation, indicating its multitarget anti-cytokine action.
Supporting agencies: the study was conducted as part of the state assignment of the Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia under the project “Sirtuin expression as a biomarker in assessing the functional states of laboratory animals” (code: SIRT-2024).
About the Authors
N. S. Ogneva
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Nastasya S. Ogneva
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
M. S. Nesterov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Maxim S. Nesterov
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
Yu. V. Fokin
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Yuriy V. Fokin, Cand. Sci. (Biol.)
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
D. V. Khvostov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Daniil V. Khvostov, Cand. Sci. (Tech.)
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
A. I. Levashova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Anna I. Levashova, Cand. Sci. (Chem.)
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
V. N. Karkischenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Vladislav N. Karkischenko, Dr. Sci. (Med.), Prof
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
References
1. Pomytkin I.A., Ogneva N.S., Fokin Yu.V., Petrova N.V., Alimkina O.V., Karkischenko V.N. Epigeneticheskie mehanizmi protivovospalitelnogo deistviya opioidnogo peptide Lejtragin: rol sirtuina 1 [Epigenetic mechanisms of the anti-inflammatory action of the opioid peptide Leitragin: role of sirtuin 1]. Biomedicina [Journal Biomed]. 2024;20(3):10–20. (In Russian). DOI: 10.33647/2074-5982-20-3-10-20.
2. Kauppinen A., Suuronen T., Ojala J., Kaarniranta K., Salminen A. Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell Signal. 2013;25(10):1939–1948. DOI: 10.1016/j.cellsig.2013.06.007.
Review
For citations:
Ogneva N.S., Nesterov M.S., Fokin Yu.V., Khvostov D.V., Levashova A.I., Karkischenko V.N. Multitarget Anti-Inflammatory Action of the Opioid Peptide Leytragin. Journal Biomed. 2026;22(1):10-14. (In Russ.) https://doi.org/10.33647/2074-5982-22-1-10-14
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