Interlinear distinctions in sensitivity to a sharp hypobaric hypoxia at inbred mice of collection fund

Abstract

The conducted research showed that mice of various genotypes possess different resistance to a sharp hypobaric hypoxia. On sensitivity to a sharp hypoxia studied genotypes can be divided into 3 categories conditionally: the low-steady – IOR/HabY, CC57WY, CBA/LacY, 101/HY; middle-steady – C3HAY, CBA/ JY and high-steady – A/SnY, B10CWY, C57BL/6Y, DBA/2Y. Distinction between highly and low-steady against a hypoxia are statistically reliable (p> 0,001). It is necessary to specify that inbred age thus has no impact on this sign. That fact testifies to it that the mice of the most highly inbred CBA/JY line who have passed 251 inbred generations, reached average position between low and high-steady genotypes. According to the received results, the studied sign possesses high variability both between animals of different lines, and between individuals in each line. High variability in sensitivity to a sharp hypoxia at animals of one genotype testifies to lack of selection on this sign. Distinctions between females and males in lines are doubtful. The exception was made by mice of the CBA/LacY line at whom males to a sharp hypoxia authentically surpassed females in sensitivity.