Research of consequences of impact of a sharp hypobaric hypoxia on male and female reproductive cells of mammals (laboratory rats and mice)

Abstract

A study of the effects of exposure to sharp hypobaric hypoxia on the reproductive cells of male and female rats and mice was held. In the experiment, low resistant to hypoxia NU/SmY lines of rats and mouse line C57BL/6Y had used, all of it was bred and maintained in SCBMT of FMBA of Russia. Sexually mature male and female rats and mice were exposed to acute hypobaric hypoxia on 9-18 day period posthypoxic mated (by type). To determine the effects of acute hypoxic stress in the germ cells of rats and mice to account embryonic mortality in the uterine period of development, the female opened by 19-20 days of pregnancy. It was found that the overall mortality in post-implantation embryos period, equal to 48.11% in female rats and 49.71% in female mice, the proportion of deaths due to the influence of acute hypoxia was 40.57% and 43.24%, respectively. Losses among the ovulated eggs in the pre-implantation stage of development in rats were 22%, in mice - 8%. Thus, the total loss caused by exposure to sharp hypobaric hypoxia exposure on male and female reproductive cells, accounted for 62.57% in female rats, in female mice - 51.24%.