The study of new potassium salt based on 3-thietanil-substituted triazole in respect to hemostasis system
Abstract
The paper shows preliminary preclinical findings of new potassium salt of 2-[3-bromine-1-(thietanil-3)-1,2,4-triazolil-5-thio]acetic acid in regards to hemostasis system. The research has determined that potassium salt of 2-[3-bromine-1-(thietanil-3)-1,2,4-triazolil-5-thio]acetic acid shows high antiaggregational activity under condition in vitro and in vivo , it is more efficient as means to experimentally prevent generalized thrombosis in comparison with the practically applied therapeutic agents. The findings allow to consider this compound a promising antithrombotic drug.
About the Authors
A. V. Samorodov
ГБОУ ВПО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
F. Kh. Kamilov
ГБОУ ВПО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
A. R. Khalimov
ГБОУ ВПО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
E. E. Klen
ГБОУ ВПО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
F. A. Khaliullin
ГБОУ ВПО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Samorodov A.V., Kamilov F.Kh., Khalimov A.R., Klen E.E., Khaliullin F.A. The study of new potassium salt based on 3-thietanil-substituted triazole in respect to hemostasis system. Journal Biomed. 2016;(3):59-67. (In Russ.)
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