Search for biologically active compounds in a series of hydrasons of NH-benzoyl-5-iodoantranylic acid
Abstract
Of particular interest in the field of synthesis are derivatives of N-substituted antranilic acid (AA), due to their versatility of biological effects and low toxicity. Structural modification of AA derivatives affects the expansion of the spectrum of pharmacological action; therefore, they have been used and are used in medical practice as antiinflammatory, analgesic, antipyretic and diuretic medicines. The aim of this work is a computer prediction using a computer program PASS Online, synthesis and experimental study of biological activity of new compounds, some substituted hydrazides of NH-acyl-5- iodantranylic acid. The synthesis of new compounds was carried out using methods of cyclization, amideation, condensation. The purity of the obtained products was controlled by TLC on plates Sorbfil PTSH-P-V. The structure of compounds was established by IR spectrometry and1H NMR spectroscopy. Antibacterial and antiinflammatory activities were studied in the laboratory. Thus, the obtained data on the prediction of the biological effect and the tests carried out testify to the prospect of searching for pharmacologically active compounds in the series of NH-benzoyl-5-iodoanthranilic acid R-benzylidenhydrazides.
About the Authors
A. F. Gazizova
ФГБОУ ВО «Пермская государственная фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
E. R. Kurbatov
ФГБОУ ВО «Пермская государственная фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
I. P. Rudakova
ФГБОУ ВО «Пермская государственная фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
A. A. Kurbatova
ФГБОУ ВО «Пермская государственная фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
E. V. Zvereva
ФГБОУ ВО «Пермская государственная фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
A. A. Bobyleva
ФГБОУ ВО «Пермская государственная фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
Yu. V. Fokin
ФГБУН Научный центр биомедицинских технологий ФМБА России
Russian Federation
Russian Federation
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Review
For citations:
Gazizova A.F., Kurbatov E.R., Rudakova I.P., Kurbatova A.A., Zvereva E.V., Bobyleva A.A., Fokin Yu.V. Search for biologically active compounds in a series of hydrasons of NH-benzoyl-5-iodoantranylic acid. Journal Biomed. 2018;(3):35-44. (In Russ.)
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