Effect of a new aminoethanol and dicarboxylic acid derivative on physical performance in aerobic training loads
Abstract
The influence of the new aminoethanol and dicarboxylic acids derivative (FDES) on endurance, swimming speed, morphological and biochemical changes in the animals during aerobic training loads was evaluated in comparison to the synthetic adaptogen with strong actoprotective action - ethylthiobenzimidalozol hydrochloride. As a result, it was found that an increase in physical performance in the application of FDES is comparable to that in the application of ethylthiobenzimidalozol hydrochloride. Animals endurance, estimated by the number of passed pools and an increase in the total swimming time, in group, which received FDES, increased by 1.92 and 3.14 times, respectively. Changes in swimming speed were not noticed in both groups. The application of FDES during training process contributes to the development of compensatory hypertrophy of myocardium.
About the Authors
S. V. Radko
ФГБОУ ВО «Санкт-Петербургская государственная химико-фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
S. V. Okovitiy
ФГБОУ ВО «Санкт-Петербургская государственная химико-фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
E. O. Gorshkova
ФГБОУ ВО «Санкт-Петербургская государственная химико-фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
M. M. Lyubishin
ФГБОУ ВО «Санкт-Петербургская государственная химико-фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
Yu. D. Bolotina
ФГБОУ ВО «Санкт-Петербургская государственная химико-фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
I. A. Berzin
ФГБОУ ВО «Санкт-Петербургская государственная химико-фармацевтическая академия» Минздрава России
Russian Federation
Russian Federation
References
1. Каркищенко Н.Н., Уйба В.В., Каркищенко В.Н., Шустов Е.Б. Очерки спортивной фармакологии. Т. 1. Векторы экстраполяции / Под ред. Н.Н. Каркищенко и В.В. Уйба. - М., СПб: Айсинг. - 2013. - 132 с.
2. Каркищенко Н.Н., Уйба В.В., Каркищенко В.Н., Шустов Е.Б, Котенко К.В., Оковитый С.В. Очерки спортивной фармакологии. Т. 2. Векторы фармакопротекции / Под ред. Н.Н. Каркищенко и В.В. Уйба. - М., СПб: Айсинг. - 2014. - 448 с.
3. Новиков В.С., Горанчук В.В., Шустов Е.Б. Физиология экстремальных состояний. - М.: Наука. - 1998. - 247 с.
4. Оковитый С.В. Актопротекторы как синтетические адаптогены нового поколения // Психофармакология и биологическая наркология. - 2003. - Т. 3. - № 1-2. - С. 510-516.
5. Оковитый С.В., Радько С.В., Шустов Е.Б. Сукцинатные рецепторы (SUCNR1) как перспективная мишень фармакотерапии // Химико-фармацевтический журнал. - 2015. - Т. 49. - № 9. - С. 24-28.
6. Оковитый С.В., Радько С.В. Применение сукцинатов в спорте // Вопросы курортологии, физиотерапии и лечебной физической культуры. - 2015. - Т. 92. - № 6. - С. 59-65.
7. Радько С.В., Оковитый С.В., Куликов А.Н., Чистякова Е.Ю. Модель оценки влияния фармакологических средств на динамику адаптации к физической нагрузке // Биомедицина. - 2016. - № 3. - С. 35-42.
8. Родичкин П.В., Оковитый С.В. Фармакологическая коррекция деятельности системы управления движениями у спортсменов высокого класса с помощью адаптогенов // Психофармакология и биологическая наркология. - 2003. - Т. 3. - № 1-2. - С. 526-531.
9. Рямова К.А., Розенфельд А.С. Поддержание работоспособности и относительного постоянства рН среды средствами субстратной поддержки митохондриального аппарата // Вестник ЮУрГУ. Серия «Образование, здравоохранение, физическая культура». - 2014. - Т.14. - № 4. - С. 14-19.
10. Савка В.Г., Радько М.М., Воробьев А.А., Марценяк И.В., Бабюк А.В. Спортивная морфология. - Черновцы: Книги XXI. - 2005. - 196 с.
11. Сыров В.Н., Шахмурова Г.А. Влияние фитоэкдистероидов и бемитила на функциональные, метаболические и иммунобиологические показатели работоспособности в эксперименте // Экспериментальная и клиническая фармакология. - 2008. - Т. 71. - № 5. - С. 40-43.
12. Цублова Е.Г., Иванова Т.Г., Иванова Т.Н., Яснецов В.В. Экспериментальная оценка актопротекторной активности производных азотсодержащих гетероциклических соединений в экстремальных условиях // Военно-медицинский журнал. - 2013. - № 7. - С. 17-19.
13. Aguiar C.J., Rocha-Franco J.A., Sousa P.A., Santos A.K., Ladeira M., Rocha-Resende C., Ladeira L.O., Resende R.R., Botoni F.A., Barrouin Melo M., Lima C.X., Carballido J.M., Cunha T.M., Menezes G.B., Guatimosim S., Leite M.F. Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation // Cell Communication and Signaling. - 2014. - V. 78. - No. 12. - Pp. 1-17.
14. Akesson B. Effects of analogues of ethanolamine and choline on phospholipid metabolism in rat hepatocytes // Biochem. J. - 1977. - V. 168. - No. 3. - Pp. 401-408.
15. Danysz A., Smietanski J., Panek W. The influence of 2-dimethylaminethanol (DMAE) on the mental and physical efficiency in man // Act. Nerv. Super. - 1967. - V. 4. - No. 9. - P. 417.
16. Ferraro E., Giammarioli A.M., Chiandotto S., Spoletini I., Rosano G. Exercise-induced skeletal muscle remodeling and metabolic adaptation: redox signaling and role of autophagy // Antioxidants & Redox Signaling. - 2014. - V. 21. - No. 1. - Pp. 154-171.
17. Haidar N.E., Carrara M., Andriamampandry C., Kanfer J.N., Freysz L., Dreyfus H., Massarelli R. Incorporation of [3H]ethanolamine into acetylcholine by a human cholinergic neuroblastoma clone // Neurochem. Res. - 1994. - V. 19. - No. 1. - Pp. 9-13.
18. Latz A., Kornetsky C., Bain G., Goldman M. Swimming performance of mice as affected by antidepressant drugs and baseline levels // Psychopharmacologia. - 1966. - V. 10. - No. 1. - Pp. 67-88.
19. Pieralisi G., Ripari P., Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanolbitartrate, vitamins, minerals, and trace elements on physical performance during exercise // Clin. Ther. - 1991. - V. 13. - No. 3. - Pp. 373-382.
20. Tonack S., Tang C., Offermanns S. Endogenous metabolites as ligands for G protein-coupled receptors modulating risk factors for metabolic and cardiovascular disease // Heart and Circulatory Physiology - Am. J. of Physiology. - 2012. - V. 304. - No. 4. - Pp. 501-513.
21. Yang L., Yu D., Fan H.H., Feng Y., Hu L., Zhang W-Y., Zhou K., Mo X-M. Triggering the succinate receptor GPR91 enhances pressure overload-induced right ventricular hypertrophy // Int. J. of Clinical and Experimental Pathology. - 2014. - V. 9. - No. 7. - Pp. 5414-28.
22. Karkischenko N.N., Uyba V.V., Karkischenko V.N., Shustov E.B. Ocherki sportivnoy farmakologii. T. 1. Vectory extrapolyacii [Sketches of sports pharmacology. Vol. 1. Extrapolation vectors]. Ed. by N.N. Karkischenko, V.V. Uyba. Moscow, Saint-Petersburg: Aysing. 2013. 132 p. (In Russian).
23. Karkischenko N.N., Uyba V.V., Karkischenko V.N., Shustov E.B., Kotenko K.V., Okovitiy S.V. Ocherki sportivnoy farmakologii. T. 2. Vectory farmakoterapii [Sketches of sports pharmacology. Vol. 1. Pharmacoprotection vectors]. Ed. by N.N. Karkischenko, V.V. Uyba. Moscow, Saint-Petersburg: Aysing. 2014. 448 p. (In Russian).
24. Novikov V.S., Goranchuk V.V., Shustov E.B. Fiziologiya extremalnyh sostojanij [Physiology of extreme conditions]. Moscow: Nauka. 1998. 247 p. (In Russian).
25. Okovitiy S.V. Aktoprotektori kak sinteticheskie adaptogeni novogo pokoleniya [Actoprotectors as synthetic adaptogens of the new generation]. Psihofarmakologiya i biologicheskaya narkologiya [Psychopharmacology and biological narcology]. 2003. V. 3. No. 1-2. Pp. 510-516. (In Russian).
26. Okovitiy S.V., Radko S.V., Shustov E.B. Sukcinatnie retseptori (SUCNR1) kak perspektivnaya mishen farmakoterapii [Succinate receptors (SUCNR1) as a promising target of pharmacotherapy]. Chemical and Pharmaceutical Journal. 2015. V. 49. No. 9. Pp. 24-28. (In Russian).
27. Okovitiy S.V., Radko S.V. Primenenie suktsinatov v sporte [The use of succinates in sports]. Voprosi kurortologii, fizioterapii i lechebnoj fizicheskoj kulturi [Questions of balneology, physiotherapy and therapeutic physical culture]. 2015. V. 92. No. 6. Pp. 59-65. (In Russian).
28. Radko S.V., Okovitiy S.V. Kulikov A.N., Chistyakova E.Yu. Model otsenki vlijaniya farmakologicheskih sredstv na dinamiku adaptacii k fizicheskoj nagruzke [Model for assessing of influence of pharmacological agents on the dynamics of adaptation to physical activity]. Biomedicine. 2016. No. 3. Pp. 35-42. (In Russian).
29. Rodichkin P.V., Okovitiy S.V. Farmakologicheskaya correktsija dejatelnosti sistemi upravleniya dvijeniyami u sportsmenov visokogo klassa c pomoshchyu adaptogenov [Pharmacological correction of the activity of the motion control system in high-class athletes using adaptogens]. Psychopharmacology and biological narcology. 2003. V. 3. No. 1-2. Pp. 526-531. (In Russian).
30. Ryamova K.A., Rozenfeld A.S. Podderjanie rabotosposobnosti i otnositelnogo postojanstva pH sredy sredstvami substratnoj podderjki mitohondrialnogo apparata [Maintaining the operability and relative constancy of the pH of the medium by means of substrate support of the mitochondrial apparatus]. Vestnik YuUrGU. Seriya «Obrazovanie, zdravoohranenie, fizicheskaya kultura» [Bulletin of the South Ural State University. Series "Education, health care, physical culture"]. 2014. V. 14. No. 4. Pp. 14-19. (In Russian).
31. Savka V.G., Radko M.M., Vorob`ev A.A., Martsenyak I.V., Babyuk A.V. Sportivnaya morfologia [Sports morphology]. Chernovtsy: Knigi XXI. 2005. 196 p. (In Russian).
32. Syrov V.N., Shakhmurova G.A. Vliyanie fitoekdisteroidov i bemitila na funktsionalnie, metabolicheskie i immunobiologicheskie pokazateli rabotosposobosti v eksperimente [Effect of phytoecdysteroids and bemithyl on functional, metabolic and immunobiological performance indicators in the experiment]. Experimental and Clinical Pharmacology. 2008. V. 71. No. 5. Pp. 40-43. (In Russian).
33. Tsublova E.G., Ivanova T.G., Ivanova T.N., Yasnetsov V.V. Eksperimentalnaya otsenka aktoprotektornoj aktivnosti proizvodnih azotsoderjashchih geterotsiklicheskih soedinenij v ekstremalnih usloviyah [Experimental evaluation of the protoprotective activity of nitrogen-containing heterocyclic compounds under extreme conditions]. Voenno-meditsinskij jurnal [Military Medical Journal]. 2013. No. 7. Pp. 17-19. (In Russian).
34. Aguiar C.J., Rocha-Franco J.A., Sousa P.A., Santos A.K., Ladeira M., Rocha-Resende C., Ladeira L.O., Resende R.R., Botoni F.A., Barrouin Melo M., Lima C.X., Carballido J.M., Cunha T.M., Menezes G.B., Guatimosim S., Leite M.F. Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation. Cell Communication and Signaling. 2014. V. 78. No. 12. Pp. 1-17.
35. Akesson B. Effects of analogues of ethanolamine and choline on phospholipid metabolism in rat hepatocytes. Biochem. J. 1977. V. 168. No. 3. Pp. 401-408.
36. Danysz A., Smietanski J., Panek W. The influence of 2-dimethylaminethanol (DMAE) on the mental and physical efficiency in man. Act. Nerv. Super. 1967. V. 4. No. 9. P. 417.
37. Ferraro E., Giammarioli A.M., Chiandotto S., Spoletini I., Rosano G. Exercise-induced skeletal muscle remodeling and metabolic adaptation: redox signaling and role of autophagy. Antioxidants & Redox Signaling. 2014. V. 21. No. 1. Pp. 154-171.
38. Haidar N.E., Carrara M., Andriamampandry C., Kanfer J.N., Freysz L., Dreyfus H., Massarelli R. Incorporation of [3H]ethanolamine into acetylcholine by a human cholinergic neuroblastoma clone. Neurochem. Res. 1994. V. 19. No. 1. Pp. 9-13.
39. Latz A., Kornetsky C., Bain G., Goldman M. Swimming performance of mice as affected by antidepressant drugs and baseline levels. Psychopharmacologia. 1966. V. 10. No. 1. Pp. 67-88.
40. Pieralisi G., Ripari P., Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanolbitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin. Ther. 1991. V. 13. No. 3. Pp. 373-382.
41. Tonack S., Tang C., Offermanns S. Endogenous metabolites as ligands for G protein-coupled receptors modulating risk factors for metabolic and cardiovascular disease. Heart and Circulatory Physiology - Am. J. of Physiology. 2012. V. 304. No. 4. Pp. 501-513.
42. Yang L., Yu D., Fan H.H., Feng Y., Hu L., Zhang W-Y., Zhou K., Mo X-M. Triggering the succinate receptor GPR91 enhances pressure overload-induced right ventricular hypertrophy. Int. J. of Clinical and Experimental Pathology. 2014. V. 9. No. 7. Pp. 5414-28.
Review
For citations:
Radko S.V., Okovitiy S.V., Gorshkova E.O., Lyubishin M.M., Bolotina Yu.D., Berzin I.A. Effect of a new aminoethanol and dicarboxylic acid derivative on physical performance in aerobic training loads. Journal Biomed. 2018;(3):101-109. (In Russ.)
Views:
297
Email this article 
