New approaches to the assessment of intracentral relations in terms of operant behavior and electrograms of the brain of cats

Insufficient informativeness of the results of standard encephalography prompts the creation of new approaches to the detection and analysis of the bioelectrical activity of the brain according to the parameters of electrograms (EG). Based on the concept of rationing the results obtained after exposure, the results of background measurements, using mathematical methods of analysis, developed a micromodule, which includes an amplifier of biopotentials, microcircuits controlling the operation of electronic devices, and original software. With the help of electrode constructions chronically implanted in prescribed areas of the brain and a micromodule, the EG of the most important brain regions were analyzed. Results have been obtained that reflect the preferential increase in the frequency-spectral characteristics of the EG when using new neuropsychotics with depriming effect in the caudate nucleus and cingulate gyrus, a decrease in the spectral power over the entire frequency range in the cerebral cortex, polyphase changes in the power of the frequencies in the posterior hypothalamus core with elements of increase and decrease power of the analyzed frequency ranges. Against the background of the use of these medicines, the threshold values of the sensitivity of the brain to electro-irritation change, and the range of their transformations is much wider than in background measurements. Different animals and drugs are characterized in general by similar operant behavioral reactions, which allow to evaluate the observed trends reflecting the effects of the drugs used. It has been shown that the caudate nucleus of the brain forms and controls stimulating reactions, and the cortex, the posterior nucleus of the hypothalamus and the end brain - inhibitory processes. Thus, when induced brain stimulation of areas of the brain and the use of pharmacological neuropsychotics with depriming effect, variations in the threshold values of sensitivity and corresponding behavioral responses characterizing changes in the intracentral relations of the brain of animals are observed. These changes correlate with brain electrograms, which increases the adequacy and reliability of the results of research of intracentral relations.

intracentral relations, neuropsychotics, operant behavior, brain bioelectrical activity, cats

1. Аладжалова H.А., Саксон M.Е., Потылицын Г.П. Статистическая связь между импульсной активностью нейронов и сверхмедленными ритмическими колебаниями потенциалов в коре головного мозга кошки // Журнал высшей нервной деятельности. - 1969. - Т. 19. - № 6. - С. 1003-08.

2. Беллами Д.К. Цифровая телефония. - М.: Радио и связь, 1986.

3. Бурбаки Н. Очерки по истории математики. - М.: Мир, 1963.

4. Генкин А.А., Медведев В.И. Прогнозирование психофизиологических состояний // Вопросы методологии и алгоритмизации. - Л.: Наука, Ленинградское отделение, 1973. - 144 с.

5. Гитлиц М.В., Лев А.Ю. Теоретические основы многоканальной связи. - М.: Радио и связь, 1985.

6. История математики с древнейших времен до начала XIX столетия / Под ред. А.Н. Колмогорова и А.П. Юшкевича. Т. 1. - М.: Наука, 1970.

7. Каркищенко Н.Н. Фармакология системной деятельности мозга. - Ростов: Ростиздат, 1975, 152с.

8. Каркищенко Н.Н., Фокин Ю.В., Каркищенко В.Н., Табоякова Л.А., Мокроусов М.И., Алимкина О.В. Конвергентная валидация интрацентральных отношений головного мозга животных // Биомедицина. - 2017. - № 3. - С. 16-39.

9. Руководство по лабораторным животным и альтернативным моделям в биомедицинских исследованиях / Под ред. Н.Н. Каркищенко, С.В. Грачева. - М.: Профиль-2С, 2010, 358 с.

10. Русалов В.М., Бодунов М.В. О факторной структуре интегральных электроэнцефалографических параметров человека // В кн.: Психофизиологические исследования интеллектуальной саморегуляции и активности. - М.: Наука, 1980. - С. 94-113.

11. Хризман Т.П., Зайцева Л.М. К вопросу о центральных механизмах зрительного опознания образов у детей (по данным ЭЭГ) // Физиология человека. - 1977. - Т. 3. - № 1. - С. 22-27.

12. Aladzhalova N.A., Sakson M.E., Potylicyn G.P. Statisticheskaya svyaz' mezhdu impul'snoj aktivnost'yu nejronov i sverhmedlennymi ritmicheskimi kolebaniyami potencialov v kore golovnogo mozga koshki [Statistical connection between the impulse activity of neurons and superslow rhythmic fluctuations of potentials in the cat's cerebral cortex]. Zhurnal vysshej nervnoj deyatel'nosti [J. of Higher Nervous Activity]. 1969. V. 19. No. 6. Pp. 1003-08. (In Russian).

13. Bellami D.K. Cifrovaya telefoniya [Digital telephony]. Moscow: Radio i svyaz', 1986. (In Russian).

14. Burbaki N. Ocherki po istorii matematiki [Essays on the history of mathematics]. Moscow: Mir, 1963. (In Russian).

15. Genkin A.A., Medvedev V.I. Prognozirovanie psihofiziologicheskih sostoyanij [Prediction of psycho-physiological states]. Voprosy metodologii i algoritmizacii [Questions of methodology and algorithmization]. Leningrad: Nauka, Leningradskoe otdelenie, 1973. 144 p. (In Russian).

16. Gitlic M.V., Lev A.Yu. Teoreticheskie osnovy mnogokanal'noj svyazi [Theoretical foundations of multi-channel communication]. Moscow: Radio i svyaz', 1985. (In Russian).

17. Istoriya matematiki s drevnejshih vremen do nachala XIX stoletiya [The history of mathematics from ancient times to the beginning of the XIX century]. Ed. by A.N. Kolmogorov and A.P. Yushkevich. V. 1. Moscow: Nauka, 1970. (In Russian).

18. Karkischenko N.N. Farmakologiya sistemnoj deyatel'nosti mozga [Pharmacology of systemic activity of the brain]. Rostov: Rostizdat, 1975, 152 p. (In Russian).

19. Karkischenko N.N., Fokin Yu.V., Karkischenko V.N., Taboyakova L.A., Mokrousov M.I., Alimkina O.V. Konvergentnaya validaciya intracentral'nyh otnoshenij golovnogo mozga zhivotnyh [Convergent validation of intracentral relationships of the brain of animals]. Biomedicine. 2017. No. 3. Pp. 16-39. (In Russian).

20. Rukovodstvo po laboratornym zhivotnym i al'ternativnym modelyam v biomedicinskih issledovaniyah [Manual on laboratory animals and alternative models in biomedical research]. Ed. by N.N. Karkischenko, S.V. Grachev. Moscow: Profil'-2S, 2010, 358 p. (In Russian).

21. Rusalov V.M., Bodunov M.V. O faktornoj strukture integral'nyh ehlektroehncefalograficheskih parametrov cheloveka [About the factor structure of the integral electroencephalographic parameters of a person]. V kn.: Psihofiziologicheskie issledovaniya intellektual'noj samoregulyacii i aktivnosti [In the book: Psychophysiological studies of intellectual self-regulation and activity]. Moscow: Nauka, 1980. Pp. 94-113. (In Russian).

22. Khrizman T.P., Zajceva L.M. K voprosu o central'nyh mekhanizmah zritel'nogo opoznaniya obrazov u detej (po dannym EhEhG) [On the question of the central mechanisms of visual identification of images in children (according to EEG)]. Fiziologiya cheloveka [Human physiology]. 1977. V. 3. No. 1. Pp. 22-27. (In Russian).