Modeling of non-alcoholic liver steatosis: features of metabolic changes in the body of laboratory animals
Abstract
The article presents an analysis of some changes occurring in laboratory mice after modeling of non-alcoholic fatty liver disease by 6-month feeding them with a high-lipid diet. It has been shown that during this period, metabolism is reorganized in the body for the primary utilization of lipids, accompanied by severe carbohydrate metabolism in the liver and skeletal muscles, activation of lipid peroxidation processes in the induction of catalase activity, and accumulation of the main carbonyl groups of proteins. The revealed restructuring of energy metabolism is supplemented by a two-fold decrease in the physical performance of animals in the test of forced swimming with a load, motor activity and motivational component of the indicative reaction in the «open field» test. The most distinct deterioration of the animals occurs at the end of 3-4 months of modeling of liver steatosis.
About the Authors
S. V. Okovitiy
ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России
Russian Federation
Russian Federation
E. B. Shustov
ФГБУН «Институт токсикологии ФМБА России»
Russian Federation
Russian Federation
M. A. Belyh
ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России
Russian Federation
Russian Federation
N. V. Kirillova
ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России
Russian Federation
Russian Federation
O. M. Spasenkova
ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России
Russian Federation
Russian Federation
A. G. Ivanov
ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России
Russian Federation
Russian Federation
A. V. Karavaeva
ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России
Russian Federation
Russian Federation
A. V. Tkacheva
ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Okovitiy S.V., Shustov E.B., Belyh M.A., Kirillova N.V., Spasenkova O.M., Ivanov A.G., Karavaeva A.V., Tkacheva A.V. Modeling of non-alcoholic liver steatosis: features of metabolic changes in the body of laboratory animals. Journal Biomed. 2018;(4):29-43. (In Russ.)
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