Assessment of toxicity in vitro of a new bandaging material

Abstract

Article presents results of the study of new bandaging material's direct contact and indirect cytotoxicity assays in comparison with cotton gauze. It have been found that in direct contact of nonwoven polymeric fibrous bandaging material (BM) with cells for 24 hours of cultivation no changes in cell morphology take place, nor does the amount of dead cells increase. These conclusions have been made by means of both a visual examination and an МТТ assay. The BM extract did not have any cytotoxic effect on the tested cells either. The obtained results allow us to make a conclusion that the BM complies with the international standard ISO 10993-5, which is applied to medical goods, and can be applied in the treatment of infected wounds in clinical practice.