Полиморфизм генов системы детоксикации ксенобиотиков и его роль в биотрансформации внутривенных анестетиков
Аннотация
Despite of wide arsenal of drugs for narcosis, existing now, quite often the anaesthesiologist is faced with the problem of optimum diagram of anaesthesia. Evaluation age, social, emotional characteristics of patient is often not enough. That is why studying SNP-polymorphisms and their influence on a metabolism of anaesthetics, probably will allow to optimize the concept of «individual approach» in anaesthesiologia. A substantial part of the individual variability of person response to drugs is related with single nucleotides polymorphisms. Drugs that are used in general anesthesia undergo polymorphic metabolism. Among these, CYP2B6, CYP3A4 and CYP2C9 play a relevant role in the metabolism of ketamine. The enzymes involved in the metabolism of thiopental are still unknown. Propofol is metabolized mainly by glucuronidation by uridine diphosphate-glucuronosyltransferases (UGTs) and by hydroxylation by CYP2B6 and CYP2C enzymes. The enzymes SULT1A1 and NQO1 participate in later steps in propofol metabolism. CYP3A4, CYP3A5, CYP2B6, CYP2C19 play significant role in later steps in propofol metabolism. CYP3A4, CYP3A5, CYP2B6, CYP2C19 play significant role in the metabolism of benzodiazepines. The present review analyses the importance of enzymes in the metabolism of anaesthetics.
Ключевые слова
Об авторах
О. А. Махарин
Ростовский государственный медицинский университет, Ростов-на-Дону
Россия
Россия
Ю. С. Макляков
Ростовский государственный медицинский университет, Ростов-на-Дону
Россия
Россия
В. М. Женило
Ростовский государственный медицинский университет, Ростов-на-Дону
Россия
Россия
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Для цитирования:
Махарин О.А., Макляков Ю.С., Женило В.М. Полиморфизм генов системы детоксикации ксенобиотиков и его роль в биотрансформации внутривенных анестетиков. БИОМЕДИЦИНА. 2012;1(3):98-107.
For citation:
Maharin O.A., S Maklyakov Yu..., Genilo V.M. Polymorphism genes of the system xenobiotics detoxycation and its role in biotransformation of intravenous anaesthetics. Journal Biomed. 2012;1(3):98-107. (In Russ.)
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