Experimental modeling of the knee osteoarthrosis in dogs

Abstract

The results of experimental modeling canine osteoarthrosis by the knee immobilization with the femoral artery transsection are presented in the work. The results of the assessment of the articular cartilage morphofunctional state evidence the development of degenerative-and-dystrophic changes manifested as the death and destruction of a part of chondrocytes, the disorder of extracellular matrix homogeneity and the decrease of the parameters evaluated by morphometry – cartilage thickness, volumetric and numerical density of chondrocytes. The changes marked appear to be a consequence of metabolic process disorders in the articular cartilage evidencing the decrease of synthesis and the predominance of catabolic processes. Under these experimental conditions the intermediate zone chondrocytes equidistant from the vascular and synovial supply factors turned out to be the most vulnerable ones.