Improving the Technology of Extraction, Preparation and Conservation of Musk Deer Extract for the Standardization and Production of Pharmaceutical Substances
https://doi.org/10.33647/2074-5982-16-1-28-41
Abstract
The development of new methods for the conservation of biological raw materials, which can be used in the production of active pharmaceutical substances, is increasingly attracting research attention. This article presents the results of comparative studies into the effectiveness of biological conservation using cryopreservation, electron beam treatment and the lactoperoxidase system. Electron beam technologies demonstrated a pronounced antimicrobial effect in the treatment of musk deer extract and other biologically active substances. A recommendation was formulated to treat musk extract with electron-beam radiation at an absorbed dose of 6 kGy (9.5 MeV) following cryopreservation at –25°C over the period of 1 year. The data obtained using the method of accelerated testing allows an extended shelf life of up to 48 months to be predicted.
For the first time, the main indicators of the quality and safety of musk deer extract as a potential raw material for the production of active pharmaceutical substances and medicinal animal raw materials were determined. A standard for the quality of musk deer extract as a raw material, as well as an experimental-industrial regulation for its preparation and preservation, were developed.
About the Authors
S. L. Lyublinskiy
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Stanislav L. Lyublinskiy – Cand. Sci. (Biol.)
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
I. N. Lyublinskaya
Scientific-Production Firm “MOBITEK-M”
Russian Federation
Russian Federation
Irina N. Lyublinskaya
249010, Kaluga region, Borovsk, Institute village, 6
V. P. Galochkina
Scientific-Production Firm “MOBITEK-M”
Russian Federation
Russian Federation
Valentina P. Galochkina – Dr. Sci. (Biol.)
249010, Kaluga region, Borovsk, Institute village, 6
E. M. Koloskova
Scientific-Production Firm “MOBITEK-M”
Russian Federation
Russian Federation
Elena M. Koloskova – Cand. Sci. (Biol.)
249010, Kaluga region, Borovsk, Institute village, 6
V. N. Karkischenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Vladislav N. Karkischenko – Dr. Sci. (Med.), Prof.
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
M. S. Nesterov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Maxim S. Nesterov
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
I. A. Berzin
Federal Medical and Biological Agency
Russian Federation
Russian Federation
Igor A. Berzin – Dr. Sci. (Med.), Prof., Honored Doctor of the Russian Federation
123182, Moscow, Volokolamskoe highway, 30
R. A. Ageldinov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Ruslan A. Ageldinov
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
R. S. Churyukin
Tekleor
Russian Federation
Russian Federation
Roman S. Churyukin – Cand. Sci. (Biol.)
249010, Kaluga region, Borovsk district, Staromikhailovskoye village, 1-ya Industrial’naya str., building 4
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Review
For citations:
Lyublinskiy S.L., Lyublinskaya I.N., Galochkina V.P., Koloskova E.M., Karkischenko V.N., Nesterov M.S., Berzin I.A., Ageldinov R.A., Churyukin R.S. Improving the Technology of Extraction, Preparation and Conservation of Musk Deer Extract for the Standardization and Production of Pharmaceutical Substances. Journal Biomed. 2020;16(1):28-41. (In Russ.) https://doi.org/10.33647/2074-5982-16-1-28-41
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