Study and Evaluation of Molecular Genetic Signs of the NFE2L2 Gene Expression during Adaptation to Physical Loads in Mini Pigs

Abstract

This article sets out to evaluate the expression of the NFE2L2 gene (Nuclear Factor, Erythroid 2 Like 2) when adapting to physical loads (achieving oxidative stress) in mini pigs. The conducted experiment reproduced natural conditions of oxidative stress in laboratory animals (16 mini pigs). Sports training is the most optimal and natural model of enhanced dissimilation as a cause of oxidative stress. The results of the study indicate that the NFE2L2 gene encoding the Nrf2 transcription factor is actively expressed in response to oxidative stress in animal cells. The NFE2L2 gene can serve as an evaluation criterion for molecular genetic studies of performance and endurance for individual selection by groups. Such evaluation can be recommended for studies aimed at revealing the effects of pharmacological drugs on the regenerative properties of the body, with the possible choice of pharmaceutical ingredients and extrapolation from animal studies to humans. An important practical result and an indicator of adaptation is increased performance. The possibility of affecting the expression of the NFE2L2 gene paves the way to enhancing the body’s ability to adapt to oxygen starvation.