Comparative Experimental Biomodelling of NSAID-induced Enterocolitis
https://doi.org/10.33647/2074-5982-16-1-65-81
Abstract
Use of non-steroidal anti-inflammatory drugs (NSAIDs) is considered to be a factor in the development of gastrointestinal tract (GIT) diseases. Thus, enterocolitis is a frequent complication of NSAIDs. Experimental modelling of GIT diseases in laboratory animals, which describes the origin and mechanism of the corresponding disease in humans with maximal precision, is an urgent problem of modern medicine. This paper presents the results of comparative experimental biomodelling of NSAID-induced enterocolitis in laboratory rats. It was found that the intragastric administration of acetylsalicylic acid resulted mainly in stomach damage. The introduction of dexketoprofen — both orally and intramuscularly — causes erosive and ulcerative lesions of the stomach and intestines. The type of damage showed no correlation with the type of administration. For the first time, the results of enterocolitis biomodelling using dexketoprofen are presented.
About the Authors
R. A. Klesov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Roman A. Klesov
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
V. N. Karkischenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Vladislav N. Karkischenko – Dr. Sci. (Med.), Prof.
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
O. I. Stepanova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Olga I. Stepanova – Cand. Sci. (Biol.)
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
O. V. Baranova
Treatment and Rehabilitation Center of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Oxana V. Baranova – Cand. Sci. (Med.)
125367, Moscow, Ivan’kovskoe highway, 3
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Review
For citations:
Klesov R.A., Karkischenko V.N., Stepanova O.I., Baranova O.V. Comparative Experimental Biomodelling of NSAID-induced Enterocolitis. Journal Biomed. 2020;16(1):65-81. (In Russ.) https://doi.org/10.33647/2074-5982-16-1-65-81
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