Drug-Induced Injury of the Gastrointestinal System and Methods for Its Correction (A Review)
https://doi.org/10.33647/2074-5982-16-3-14-34
Abstract
Common complications of pharmacotherapy involve damage to the gastrointestinal tract, development of resistance to traditional therapy, destruction of the intramural nervous system of the intestines, changes in the opportunistic microflora, dysfunctions of the intestinal immune system. According to WHO experts, diseases of the digestive system are expected to become one of the leading causes of disability. This paper reviews current publications on drug-induced injuries of the gastrointestinal tract, including those induced by drugs aimed at preventing such conditions. Side effects of NSAIDs, glucocorticoids, minerals, neuroleptics, antibiotics, cytostatics, saluretics, anticoagulants, contraceptives, as well as enemas, suppositories and other drugs are described. Published review papers paid significant attention to drug-induced injuries of the stomach; however, there is a lack of data on drug-induced lesions of the gastrointestinal tract. This paper aims to brigde this gap. New approaches to correction and organ protection are described. The epigenetic issues related to the pluripotency of stem cells are considered. In the Russian Federation, a regulatory framework was created to regulate all the fundamental processes associated with the production and use of biomedical cell products and biotechnologies.
About the Authors
R. A. Klesov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Roman A. Klesov
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
N. N. Karkischenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Nikolay N. Karkischenko, Dr. Sci. (Med.), Prof., Academician of the Russian Academy of Rocket and Artillery Sciences, Corresponding Member of the Russian Academy of Sciences
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
O. I. Stepanova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Olga I. Stepanova, Cand. Sci. (Biol.)
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
E. L. Matveyenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Elena L. Matveyenko, Cand. Sci. (Econ.)
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
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For citations:
Klesov R.A., Karkischenko N.N., Stepanova O.I., Matveyenko E.L. Drug-Induced Injury of the Gastrointestinal System and Methods for Its Correction (A Review). Journal Biomed. 2020;16(3):14-34. (In Russ.) https://doi.org/10.33647/2074-5982-16-3-14-34
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