Pharmaco-EEG as a Method for Determining the Threshold Dose of Neurotropic Substances
https://doi.org/10.33647/2074-5982-16-3-39-42
Abstract
By changing the neurochemical balance of the brain, neurotropic substances affect its bioelectric activity. For each class of such substances, their unique pattern of affecting EEG can be determined by pharmaco-EEG. The moment, when specific EEG patterns appear, manifests the achievement of a threshold dose. We propose a formula for calculating the threshold dose, which relates the infusion rate of a substance and the appearance of specific EEG patterns. This approach can complement existing methods for determining the threshold dose and increase the validity of the data obtained.
About the Authors
O. A. Yakovlev
State Scientific Research Test Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Oleg A. Yakovlev
195043, Saint Petersburg, Lesoparkovaya str., 4
M. S. Vakhviyaynen
State Scientific Research Test Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Mariia S. Vakhviyaynen
195043, Saint Petersburg, Lesoparkovaya str., 4
M. A. Yudin
State Scientific Research Test Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Mikhail A. Yudin, Dr. Sci. (Med.), Assoc. Prof.
195043, Saint Petersburg, Lesoparkovaya str., 4
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Review
For citations:
Yakovlev O.A., Vakhviyaynen M.S., Yudin M.A. Pharmaco-EEG as a Method for Determining the Threshold Dose of Neurotropic Substances. Journal Biomed. 2020;16(3):39-42. (In Russ.) https://doi.org/10.33647/2074-5982-16-3-39-42
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