Comparative Analysis of the Exploratory Activity of Rats Following the Administration of Liquid Aerosol Using “Nose Only” and “Whole Body” Inhalation Chambers
https://doi.org/10.33647/2074-5982-16-3-60-63
Abstract
The use of various models of inhalational drug administration in pre-clinical studies is strongly limited due to the influence of liquid aerosol on the exploratory behaviour of small laboratory rodents. There are two approaches to modelling inhalational administration, which involve two types of chambers: “whole-body” and “nose-only”. In this work, we compared a change in the parameters of exploratory behaviour depending on the type of chambers used.
About the Authors
M. S. Vakhviyaynen
State Scientific Research Test Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Mariya S. Vakhviyaynen
195043, Saint Petersburg, Lesoparkovaya str., 4
A. M. Sventitskaya
State Scientific Research Test Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Alevtina M. Sventitskaya
195043, Saint Petersburg, Lesoparkovaya str., 4
A. M. Kolesnikov
State Scientific Research Test Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Aleksandr M. Kolesnikov, Cand. Sci. (Biol.)
195043, Saint Petersburg, Lesoparkovaya str., 4
A. S. Nikiforov
State Scientific Research Test Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Aleksandr S. Nikiforov, Dr. Sci. (Biol.), Assoc. Prof.
195043, Saint Petersburg, Lesoparkovaya str., 4
O. A. Yakovlev
State Scientific Research Test Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Oleg A. Yakovlev
195043, Saint Petersburg, Lesoparkovaya str., 4
References
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Review
For citations:
Vakhviyaynen M.S., Sventitskaya A.M., Kolesnikov A.M., Nikiforov A.S., Yakovlev O.A. Comparative Analysis of the Exploratory Activity of Rats Following the Administration of Liquid Aerosol Using “Nose Only” and “Whole Body” Inhalation Chambers. Journal Biomed. 2020;16(3):60-63. (In Russ.) https://doi.org/10.33647/2074-5982-16-3-60-63
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