Experimental assessment of the risk of hemorrhagic complications following parenteral administration of direct anticoagulants: dabigatran etexilate and rivaroxaban
Abstract
We investigated the efficacy and safety of dabigatran etexilate and rivaroxaban after subcutaneous administration to rats. Heparin sodium was used as a reference drug. It was revealed that 2 hours following heparin sodium administration (250; 500; 1000 U/kg), dabigatran etexilate (4,0; 5,0; 7,5; 10,0; 15,0 mg/kg) and rivaroxaban (2,5; 5,0; 7,5; 10,0 mg/kg) have pronounced anticoagulant effect. Heparin sodium (1000 U/kg) and rivaroxaban (10,0 mg/kg) caused a significant prolongation of rat tail bleeding time and a critical increase in parameters of blood coagulation. Dabigatran etexilate was shown to be of higher therapeutical possibility than heparin sodium and rivaroxaban. Our results can justify the development of injectable dosage form of dabigatran etexilate. It may be important to improve the treatment of critical states with high risk of disseminated intravascular coagulation in emergency and military conflicts.
About the Authors
V. A. Pugach
ФГБУ «Государственный научно-исследовательский испытательный институт военной медицины» Министерства обороны России
Russian Federation
Russian Federation
M. A. Tyunin
ФГБУ «Государственный научно-исследовательский испытательный институт военной медицины» Министерства обороны России
Russian Federation
Russian Federation
E. A. Tarasov
ФГБУ «Государственный научно-исследовательский испытательный институт военной медицины» Министерства обороны России
Russian Federation
Russian Federation
A. S. Gogolevskiy
ФГБУ «Государственный научно-исследовательский испытательный институт военной медицины» Министерства обороны России
Russian Federation
Russian Federation
E. I. Strokina
ФГБУ «Государственный научно-исследовательский испытательный институт военной медицины» Министерства обороны России
Russian Federation
Russian Federation
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Review
For citations:
Pugach V.A., Tyunin M.A., Tarasov E.A., Gogolevskiy A.S., Strokina E.I. Experimental assessment of the risk of hemorrhagic complications following parenteral administration of direct anticoagulants: dabigatran etexilate and rivaroxaban. Journal Biomed. 2018;(4):79-87. (In Russ.)
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