Some Aspects of the Effect of Combined Irradiation by Gamma-Rays and Carbon Nuclei (12C) on the Serotonergic System in Rat Brain
https://doi.org/10.33647/2074-5982-16-3-68-72
Abstract
The atomic nuclei of cosmic rays possessing a high kinetic energy pose a significant threat to living organisms outside the Earth’s magnetic field. However, surprisingly, a series of ground-based studies using progressive models of combined irradiation revealed positive effects of such rays in relation to the functions of the central nervous system. The molecular mechanism of this phenomenon remains unknown. We have previously proposed a hypothesis that the serotonergic system may be involved in the realization of these effects. This research investigates the content of a number of biomolecules participating in serotonergic neurotransmission in selected morphological brain structures of rats under combined (γ-rays and 12C6+) irradiation. The revealed increase in 5-HT2a in the prefrontal cortex may be a key link in the mechanism responsible for enhancing cognitive functions under moderate doses of ionizing radiation.
About the Author
V. S. Kokhan
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Viktor S. Kokhan, Cand. Sci. (Biol.)
143442, Moscow region, Krasnogorsk district, Svetlye gory village, building 1
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Review
For citations:
Kokhan V.S. Some Aspects of the Effect of Combined Irradiation by Gamma-Rays and Carbon Nuclei (12C) on the Serotonergic System in Rat Brain. Journal Biomed. 2020;16(3):68-72. (In Russ.) https://doi.org/10.33647/2074-5982-16-3-68-72
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