Effects of Dexamethasone on the Course of Intoxication when Modelling Mustard Gas Inhalation Injury
https://doi.org/10.33647/2074-5982-16-3-111-114
Abstract
The current work assesses the efficacy of a course of intramuscular administration of dexamethasone at doses of 1 or 4 mg/kg when modelling sulphur mustard aerosol inhalation injury. To this end, the average lethal doses, the median death time and the protection coefficients were calculated for rats with sulphur mustard inhalation injury induced by a micro-sprayer. In the treatment regimen used, dexamethasone showed low levels of efficacy, possibly due to its pleiotropic effect on the immune system.
About the Authors
K. A. Bulka
S.M. Kirov Military Medical Academy of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Kirill A. Bulka
194044, Saint Petersburg, Lebedeva str., 6
S. P. Sidorov
State Scientific Research Test Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Sergey P. Sidorov, Cand. Sci. (Med.)
195043, Saint Petersburg, Lesoparkovaya str., 4
O. V. Chubar
State Scientific Research Test Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Oleg V. Chubar, Dr. Sci. (Med.)
195043, Saint Petersburg, Lesoparkovaya str., 4
M. A. Metelitsa
State Scientific Research Test Institute of Military Medicine of the Ministry of Defence of Russia
Russian Federation
Russian Federation
Mariya A. Metelitsa
195043, Saint Petersburg, Lesoparkovaya str., 4
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Review
For citations:
Bulka K.A., Sidorov S.P., Chubar O.V., Metelitsa M.A. Effects of Dexamethasone on the Course of Intoxication when Modelling Mustard Gas Inhalation Injury. Journal Biomed. 2020;16(3):111-114. (In Russ.) https://doi.org/10.33647/2074-5982-16-3-111-114
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