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Polyprenols as Promising Neuropharmacological Agents

https://doi.org/10.33647/2074-5982-16-3-125-129

Abstract

The article presents information about the potential effectiveness of polyprenols as a means of neuropharmacology. To confirm the neuroprotective effect of polyprenols, their effectiveness was studied in the case of chronic exposure to carbendazim. In such conditions, chronic damage to nerve cells is developed through violating the homeostasis of neurospecific proteins (S-100, MBP) and trophic factors, as well as a sharp activation of lipid peroxidation processes. The administration of polyphenols (2 mg/kg once a day for 2 weeks) to laboratory animals under modelled conditions reduced the manifestations of neurointoxication and statistically significantly contributed to the reduction of oxidative stress and activation of antioxidant defence enzymes (glutathione-S-transferase).

About the Authors

E. B. Shustov
Institute of Toxicology of the Federal Medical and Biological Agency of Russia; Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation

Evgeny B. Shustov, Dr. Sci. (Med.), Prof.

192019, Saint Petersburg, Behtereva str., 1
197376, Saint Petersburg, Professora Popova str., 14 



V. A. Kashuro
Institute of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation

Vadim A. Kashuro, Dr. Sci. (Med.)

192019, Saint Petersburg, Behtereva str., 1



E. G. Batotsyrenova
Institute of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation

Ekaterina G. Batotsyrenova, Cand. Sci. (Biol.)

192019, Saint Petersburg, Behtereva str., 1



E. A. Zolotoverhaya
Institute of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation

Ekaterina A. Zolotoverhaya, Cand. Sci. (Biol.)

192019, Saint Petersburg, Behtereva str., 1



A. E. Kim
S.M. Kirov Military Medical Academy of the Ministry of Defence of Russia
Russian Federation

Alexey E. Kim, Cand. Sci. (Med.)

194044, Saint Petersburg, Lebedeva str., 6



T. A. Kostrova
Institute of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation

Taisiya A. Kostrova

192019, Saint Petersburg, Behtereva str., 1



References

1. Bakunina N.S., Glushakov R.I., Tapilskaya N.I., Shabanov P.D. Farmacologiya poliprenolov kak adaptogenov, snizhayuschih intensivnost processov glikirovaniya [Pharmacology of polyprenols as adaptogens that reduce the intensity of glycation processes]. Obzory po klinicheskoy farmakologii i lekarstvennoi terapii [Reviews of Clinical Pharmacology and Drug Therapy]. 2013;11(4):44–53. (In Russian).

2. Muhametova Yu.R. Harakteristika deistvuyushih nachal i vosmozhnih mexanismov vliyaniya poliprenolov na obmennye processy [Characteristics of the active principles and possible mechanisms of influence of polyprenols on metabolic processes]. In: Pischa. Ecologiya. Kachestvo: Trudy XIV mezhdunarodnoy nauchno-practicheskoy konferencii [Food. Ecology. Quality: Proceedings of the XIV international scientific and practical conference]. Moscow, 2017. P. 70–72. (In Russian).


Review

For citations:


Shustov E.B., Kashuro V.A., Batotsyrenova E.G., Zolotoverhaya E.A., Kim A.E., Kostrova T.A. Polyprenols as Promising Neuropharmacological Agents. Journal Biomed. 2020;16(3):125-129. (In Russ.) https://doi.org/10.33647/2074-5982-16-3-125-129

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ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)