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Effects of Delta-sleep-inducing, Kisspeptin-10 and pt-141 Neuropeptides on Sexual Behaviour in Male Rats

https://doi.org/10.33647/2074-5982-17-1-43-56

Abstract

The work presents a comparative assessment of the effects of delta-sleep-inducing peptide (DSIP), kiss-peptin-10 and PT-141 neuropeptides on the copulatory behaviour in male rats with natural sexual activity.

A single intraperitoneal injection of DSIP (1 mg/kg) promotes the motivational and copulatory components of sexual male rat behaviour in courtship of a receptive female. The neuropeptide application significantly boosts sexual activity in males, rises the copulation rate, mean number of ejaculations towards sexual exhaustion and reduces rest periods in animals. Kisspeptin-10 (1 mg/kg) promotes high arousal in the middle (increased copulation rate in copulatory series 6) and end of the courtship cycle (increased ratio of sexually active males in copulatory series 8-9). PT-141 (0.13 mg/kg) facilitates sexual activity in male rats only in the onset and middle of the courtship cycle. The transience of DSIP and PT-141 stimulating effect warrants adjustments in the neuropeptide dosage and application regimens.

About the Authors

S. N. Subbotina
State Research Testing Institute of Military Medicine of the Ministry of Defense of Russia
Russian Federation

Svetlana N. Subbotina - Cand. Sci. (Biol.)

195043, Saint Petersburg, Lesoparkovaya Street, 4



M. A. Yudin
State Research Testing Institute of Military Medicine of the Ministry of Defense of Russia
Russian Federation

Mikhail A. Yudin - Dr. Sci. (Med.), Assoc. Prof.

195043, Saint Petersburg, Lesoparkovaya Street, 4



A. A. Parfyonova
State Research Testing Institute of Military Medicine of the Ministry of Defense of Russia
Russian Federation

Anastasiya A. Parfyonova

195043, Saint Petersburg, Lesoparkovaya Street, 4



A. A. Kryazhevskikh
State Research Testing Institute of Military Medicine of the Ministry of Defense of Russia
Russian Federation

Aleksey A. Kryazhevskikh

195043, Saint Petersburg, Lesoparkovaya Street, 4



A. B. Orlova
State Research Testing Institute of Military Medicine of the Ministry of Defense of Russia
Russian Federation

Anastasiya B. Orlova

195043, Saint Petersburg, Lesoparkovaya Street, 4



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For citations:


Subbotina S.N., Yudin M.A., Parfyonova A.A., Kryazhevskikh A.A., Orlova A.B. Effects of Delta-sleep-inducing, Kisspeptin-10 and pt-141 Neuropeptides on Sexual Behaviour in Male Rats. Journal Biomed. 2021;17(1):43-56. (In Russ.) https://doi.org/10.33647/2074-5982-17-1-43-56

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