Drug Correction of Hypoxic Thermal Impact on Organismal Functional State

The study experimentally modelled the functional state in laboratory animals under haemic hypoxia combined with thermal exposure (hyper- or hypothermia) by estimating their physical capacity with the forced swim test. Trimetazidine has been proved an effective drug agent for the correction of hypoxic hyperthermal response in a two-factor model due to its marked antihypoxic effect observed under haemic hypoxia and hypoxia combined with hyperthermia. Relative to haemic hypoxia and hypothermia, the drugs studied can be separated between three groups by corrective efficiency: weak protectors (150-200% of control level, Flamenco 250 mg/kg, trimetazidine), moderate protectors (200-300%, polypeptide mix, Flamenco 50 and 75 mg/kg, Hypoxen) and effective protectors (>300%, course intake of specialised “MioActive Sport” nutrition additive).

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