The experimental study of the antihypoxic properties of harmine hydrochloride
https://doi.org/10.33647/2074-5982-17-2-71-78
Abstract
A derivative of the beta-carboline alkaloid harmine — the drug harmine hydrochloride was studied for the presence of antihypoxic properties in models of hypobaric hypoxia and normobaric hypoxia with hypercapnia. It was found that harmine hydrochloride does not have a signifi cant compensatory effect in the normobaric hypoxia test with hypercapnia. At the same time, harmine hydrochloride in small doses (2.5 and 5 mg/kg) has antihypoxic activity in the hypobaric hypoxia test, which is expressed in a statistically signifi cant increase in the life expectancy of animals treated with the drug, compared with the control, in conditions of hypoxia. According to the antihypoxic effect, harmine hydrochloride at doses of 2.5 and 5 mg/kg was found to be comparable with the reference drug (mexidol, 100 mg/kg).
About the Authors
S. M. Adekenov
International Research and Production Holding “Phytochemistry”
Kazakhstan
Kazakhstan
Sergazy M. Adekenov, Dr. Sci. (Chem.), Prof., Acad. of the National Academy of Sciences of the Republic of Kazakhstan
100009, Karaganda, M. Gazalieva Str., 4
V. N. Karkischenko
Scientifi c Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Vladislav N. Karkischenko, Dr. Sci. (Med.), Prof.
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
M. S. Nesterov
Scientifi c Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Maxim S. Nesterov
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
D. A. Abaimov
Scientific Center of Neurology
Russian Federation
Russian Federation
Denis A. Abaimov, Cand. Sci. (Biol.)
125367, Moscow, Volokolamskoe Highway, 80
A. K. Sariev
First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health care of Russia (Sechenov University)
Russian Federation
Russian Federation
Abrek K. Sariev, Dr. Sci. (Med.), Prof.
119991, Moscow, Trubetskaya Str., 8, building 2
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Review
For citations:
Adekenov S.M., Karkischenko V.N., Nesterov M.S., Abaimov D.A., Sariev A.K. The experimental study of the antihypoxic properties of harmine hydrochloride. Journal Biomed. 2021;17(2):71-78. (In Russ.) https://doi.org/10.33647/2074-5982-17-2-71-78
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