Mechanisms of the Cytotoxic Action of Organotin Compounds
https://doi.org/10.33647/2074-5982-17-2-88-99
Abstract
This review analyzed the literature data on the in vitro preclinical study of the cytotoxic properties of organotin compounds, as well as the main mechanisms of their action. The latter consist in interacting with SH groups of proteins, initiating oxidative stress, binding to DNA, interacting with receptors, as well as activate apoptosis by increasing the expression of caspases, proapoptotic proteins, and decreasing antiapoptotic proteins. Organotin compounds, depending on the donor ligand, exhibit specifi c cytotoxicity towards certain tumor cell lines. The high cytotoxic potential indicates the possibility of further development in vivo and research of organotin compounds as candidates for the creation of drugs for anticancer and antimetastatic therapy.
About the Authors
E. R. MilaevaRussian Federation
Elena R. Milaeva, Dr. Sci. (Chem.), Prof.
119991, Moscow, Leninskie gory Str., 1, building 3
M. A. Dodokhova
Russian Federation
Margarita A. Dodokhova, Cand. Sci. (Med.), Assoc. Prof.
344022, Rostov-on-Don, Nakhichevansky Lane, 29
D. B. Shpakovsky
Russian Federation
Dmitry B. Shpakovsky, Cand. Sci. (Chem.)
119991, Moscow, Leninskie gory Str., 1, building 3
T. A. Antonenko
Russian Federation
Taisiya A. Antonenko, Cand. Sci. (Chem.)
119991, Moscow, Leninskie gory Str., 1, building 3
A. V. Safronenko
Russian Federation
Andrey V. Safronenko, Dr. Sci. (Med.), Assoc. Prof.
344022, Rostov-on-Don, Nakhichevansky Lane, 29
I. M. Kotieva
Russian Federation
Inga M. Kotieva, Dr. Sci. (Med.), Assoc. Prof.
344022, Rostov-on-Don, Nakhichevansky Lane, 29
E. F. Komarova
Russian Federation
Ekaterina F. Komarova, Dr. Sci. (Biol.), Prof., Prof. of RAS
344022, Rostov-on-Don, Nakhichevansky Lane, 29
E. V. Gantsgorn
Russian Federation
Elena V. Gantsgorn, Cand. Sci. (Med.)
344022, Rostov-on-Don, Nakhichevansky Lane, 29
M. S. Alkhuseyn-Kulyaginova
Russian Federation
Margarita S. Alkhuseyn-Kulyaginova
344022, Rostov-on-Don, Nakhichevansky Lane, 29
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Review
For citations:
Milaeva E.R., Dodokhova M.A., Shpakovsky D.B., Antonenko T.A., Safronenko A.V., Kotieva I.M., Komarova E.F., Gantsgorn E.V., Alkhuseyn-Kulyaginova M.S. Mechanisms of the Cytotoxic Action of Organotin Compounds. Journal Biomed. 2021;17(2):88-99. (In Russ.) https://doi.org/10.33647/2074-5982-17-2-88-99